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Cat. No.: HY-W714099

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U 66985

U 66985 is a platelet-activating factor (PAF) receptor antagonist. U 66985 binds to the PAF receptor site, thereby inhibiting PAF-induced platelet aggregation. U 66985 can be used in studies on the PAF signaling pathway and the functions of lipid inflammatory mediators^[1][2].

For research use only. We do not sell to patients.

CAS No.: 99103-16-9
Formula: C₃₂H₆₆NO₇P
Molecular Weight:607.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

U 66985 Chemical Structure

CAS No.: 99103-16-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

U 66985 (radioimmunoassay; incubation at room temperature overnight) inhibits the binding of [¹²⁵I]PAF to anti-PAF antibody from rabbit A, with a 50% inhibitory amount of 19 pmol/tube^[1]
U 66985 (1 μM; HAG 10 μg/mL; pre-perfused for 5 min prior to HAG stimulation; isolated perfused liver of Sprague-Dawley rats) does not reduce the HAG-induced glycogenolysis response; the maximum increase in glucose release upon U 66985 treatment is 81 μmol/h/g, compared with 80 μmol/h/g in the parallel control group^[2].
U 66985 (1 μM; isolated perfused Sprague-Dawley rat liver; pretreated starting at 35 min of perfusion, followed by perfusion with 1 nM [³H]18:0-sn-3-AGEPC during 40-42 min) does not significantly alter the silver grain distribution of [³H]AGEPC in liver tissues; in this experiment, U 66985 is present at a 1000-fold excess relative to the radioligand^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 99103-16-9
Molecular Weight 607.85
Formula C₃₂H₆₆NO₇P
SMILES

[C@H](COP(OCCCCCC[N+](C)(C)C)(=O)[O-])(COCCCCCCCCCCCCCCCCCC)OC(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Cooney SJ, et al. Combining site specificities of rabbit antibodies to platelet-activating factor (PAF). Molecular immunology. 1990 May;27(5):405-12.

[2]. Buxton DB, et al. Glycogenolytic and haemodynamic responses to heat-aggregated immunoglobulin G and prostaglandin E2 in the perfused rat liver. The Biochemical journal. 1987 Apr 15;243(2):493-8.

[3]. Hill CE, et al. Location of platelet activating factor binding in rat liver. The Biochemical journal. 1988 Aug 01;253(3):651-7.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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