UNC8899
UNC8899 is a STING PROTAC degrader with a DC50 of 1.097 μM. UNC8899 recruits the VHL E3 ligase to mediate the ubiquitination of phosphorylated STING and subsequent proteasomal degradation. UNC8899 can be used in studies of renal cell carcinoma.
(Pink: STING ligand (HY-184545); Blue: VHL ligand (HY-138678B); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 3094059-37-4
- Formula: C71H91N17O13S
- Molecular Weight:1422.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
[1]|
VHL |
In Vitro
UNC8899 (0-31.6 μM；24 h) degrades STING in Caki-1 cells, with a DC50 of 1.097 μM and a Dmax of 99.94%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Caki-1
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Concentration:0.01, 0.0316, 0.1, 0.316, 1, 3.16, 10, 31.6 μM
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Incubation Time:24 h
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Result:Degraded STING in Caki-1 cells, with a DC50 of 1.097 μM and a Dmax of 99.94%.
Chemical Information
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CAS No. 3094059-37-4
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Molecular Weight 1422.65
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Formula C71H91N17O13S
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SMILES
O=C(NCCOCCOCCC(N[C@@H](C(N1[C@H](C(NCC2=CC=C(C=C2)C3=C(C)N=CS3)=O)C[C@H](C1)O)=O)C(C)(C)C)=O)C4=CC5=C(C(OC)=C4)N(C/C=C/CN6C(NC(C7=CC(C)=NN7CC)=O)=NC8=C6C(OCCCN9CCOCC9)=CC(C(N)=O)=C8)C(NC(C%10=CC(C)=NN%10CC)=O)=N5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
UNC8899 Related Classifications
HY-158046 Related Classifications
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