PDE9A - phosphodiesterase 9A Gene

Also Known as HSPDE9A2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5152

About PDE9A

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,653,621-42,775,509 (from NCBI)

This gene has 28 transcripts (splice variants), 192 orthologues and 20 paralogues. Broad expression in colon (RPKM 12.5), prostate (RPKM 9.8) and 17 other tissues.

Summary

The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PDE9A Products (24)

mRNA Protein Name
NM_001001576.2 NP_001001576.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j
XM_011529598.3 XP_011527900.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1
NM_001001584.3 NP_001001584.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
NM_001001583.2 NP_001001583.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform o
NM_001001568.2 NP_001001568.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform c
NM_001001573.2 NP_001001573.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
NM_001001572.2 NP_001001572.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
NM_001001567.2 NP_001001567.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform b
NM_001001569.2 NP_001001569.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform d
XM_011529600.3 XP_011527902.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X2
NM_001001581.2 NP_001001581.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform m
NM_001001575.2 NP_001001575.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform i
NM_001001578.2 NP_001001578.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform l
NM_001001585.2 NP_001001585.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
XM_017028366.2 XP_016883855.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X3
NM_002606.3 NP_002597.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a
NM_001001579.2 NP_001001579.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform g
NM_001001571.2 NP_001001571.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform f
NM_001001582.2 NP_001001582.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform n
NM_001001577.2 NP_001001577.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform k
NM_001001570.2 NP_001001570.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform e
NM_001315533.2 NP_001302462.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform p
NM_001001574.2 NP_001001574.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform h
NM_001001580.2 NP_001001580.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform j

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
IDA: Inferred from direct assay
9624146 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
26871637 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in cGMP catabolic process IDA
IDA: Inferred from direct assay
25799991 GOA
involved in cGMP metabolic process IDA
IDA: Inferred from direct assay
9624146 GOA
Cellular Component GO Annotation Evidence References Source
located in sarcolemma IDA
IDA: Inferred from direct assay
25799991 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE9A Protein Structure

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (311 - 534)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 593 a.a.
Protein Preferred Names Protein Names

high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

  • CGMP-specific 3',5'-cyclic phosphodiesterase type 9

  • phosphodiesterase PDE9A21

PDE9A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PDE9A O76083 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
Intra
PDE9A O76083 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra
PDE9A O76083 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra
PDE9A O76083 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
25416956
Intra
PDE9A O76083 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Array
25416956
Intra
PDE9A O76083 LINC02913 Homo sapiens Q8NAJ2
Validated Y2H
25416956
Intra
PDE9A O76083 LINC02913 Homo sapiens Q8NAJ2
Y2H Array
25416956
Intra
PDE9A O76083 LINC02913 Homo sapiens Q8NAJ2
Y2H Prey Pooling
25416956
Intra
PDE9A O76083 PHYHIPL Homo sapiens Q96FC7-2
Y2H Array
25416956
Intra
PDE9A O76083 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
25416956
Intra
PDE9A O76083 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
25416956
Intra
PDE9A O76083 LAGE3 Homo sapiens Q14657
Validated Y2H
25416956
Intra
PDE9A O76083 PDE9A Homo sapiens O76083-2
Y2H Array
26871637
Intra
PDE9A O76083 PDE9A Homo sapiens O76083-2
Y2H Prey Pooling
26871637
Intra
PDE9A O76083 PDE9A Homo sapiens O76083-2
Validated Y2H
26871637
Intra
PDE9A O76083 CRY2 Homo sapiens Q49AN0
Validated Y2H
25416956
Intra
PDE9A O76083 CLK1 Homo sapiens P49759
Y2H Array
25416956
Intra
PDE9A O76083 UTP23 Homo sapiens Q9BRU9
Y2H Array
25416956
Intra
PDE9A O76083 SULT1E1 Homo sapiens P49888
Y2H Array
25416956
Intra
PDE9A O76083 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
25416956
Intra
PDE9A O76083 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
25416956
Intra
PDE9A O76083 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
25416956
Intra
PDE9A O76083 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
29892012
Intra
PDE9A O76083 LMO2 Homo sapiens P25791
Y2H Prey Pooling
25416956
Intra
PDE9A O76083 LMO2 Homo sapiens P25791
Validated Y2H
25416956
Intra
PDE9A O76083 LMO2 Homo sapiens P25791
Y2H Array
25416956
Intra
PDE9A O76083 TRIM32 Homo sapiens Q13049
Y2H Pooling
16189514
Intra
PDE9A O76083 TRIM32 Homo sapiens Q13049
Y2H Array
31515488
Intra
PDE9A O76083 TRIM32 Homo sapiens Q13049
Y2H Prey Pooling
25416956
Intra
PDE9A O76083 TRIM32 Homo sapiens Q13049
Y2H Prey Pooling
26871637
Intra
PDE9A O76083 TRIM32 Homo sapiens Q13049
Y2H Array
19060904
Intra
PDE9A O76083 TRIM32 Homo sapiens Q13049
Validated Y2H
26871637
Intra
PDE9A O76083 TRIM32 Homo sapiens Q13049
Y2H Array
25416956
Intra
PDE9A O76083 TRIM32 Homo sapiens Q13049
Y2H Array
26871637
Intra
PDE9A O76083 TRIM32 Homo sapiens Q13049
Y2H Pooling
19060904
Intra
PDE9A O76083 BAG3 Homo sapiens O95817
Y2H Array
25416956
Intra
PDE9A O76083 BAG3 Homo sapiens O95817
Y2H Prey Pooling
25416956
Intra
PDE9A O76083 BAG3 Homo sapiens O95817
Validated Y2H
25416956
Intra
PDE9A O76083 ZFAB Homo sapiens Q9Y260
Validated Y2H
25416956
Intra
PDE9A O76083 ZFAB Homo sapiens Q9Y260
Y2H Array
25416956
Intra
PDE9A O76083 ZFAB Homo sapiens Q9Y260
Y2H Prey Pooling
25416956
Intra
PDE9A O76083 NAA38 Homo sapiens Q9BRA0
Validated Y2H
25416956
Intra
PDE9A O76083 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
Intra
PDE9A O76083 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PDE9A Proteins

Cat. No. Product Name Accession Purity
HY-P75962 PDE9A Protein, Human (sf9, His-GST) O76083-2 (M1-A533) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75963 PDE9A Protein, Human (His) O76083-2 (P181-K506) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Cecum Adenocarcinoma

  • Cecal Adenocarcinoma

  • Adenocarcinoma Of Cecum
Heart Disease

  • Heart Failure

  • Congenital Heart Disease

  • Heart Diseases

  • Congenital Heart Defects

  • Congenital Heart Defect

  • Congenital Anomaly Of Heart

  • Heart Defect

  • Heart Malformation

  • Heart-Congenital Defect

  • Congenital Heart Disorder

  • Heart Defects Congenital

  • Heart Defects, Congenital

  • Heart Defects

  • Heart Disease, Congenital

  • Disease, Heart, Congenital

  • Congestive Heart Failure
Transient Global Amnesia

  • Amnesia, Transient Global
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-15441 Edelinontrine Inhibitor 99.85% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.94% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-104028 BAY 73-6691 Inhibitor 99.38% Unkown
HY-12788 PF-04449613 Inhibitor 99.83% Unkown
HY-126137 PDE9-IN-1 Inhibitor 99.70% Unkown
HY-152106 BAY-7081 Inhibitor 99.03% Unkown
HY-104028B (S)-BAY 73-6691 Control 99.71% Unkown
HY-12788A (S)-PF-04449613 Inhibitor 99.85% Unkown
HY-152106A (+)-BAY-7081 Inhibitor 99.21% Unkown
HY-152106B (±)-BAY-7081 Inhibitor 99.06% Unkown
HY-RS10246 PDE9A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10247 Pde9a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10248 Pde9a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PDE9A VGNC VGNC:75925
Bos taurus PDE9A VGNC VGNC:32688
Rattus norvegicus PDE9A RGD RGD:621035
Mus musculus PDE9A MGD MGI:1277179
Felis catus PDE9A VGNC VGNC:68767
Canis familiaris PDE9A VGNC VGNC:44367
Others PDE9A NCBI