PSMC2 - proteasome 26S subunit, ATPase 2 Gene

Also Known as S7; MSS1; RPT1; Nbla10058

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5701

About PSMC2

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:103,347,524-103,369,395 (from NCBI)

This gene has 16 transcripts (splice variants), 221 orthologues and 5 paralogues. Ubiquitous expression in adrenal (RPKM 22.7), kidney (RPKM 22.5) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in Proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2011]

PSMC2 Products (2)

mRNA Protein Name
NM_001204453.1 NP_001191382.1 26S proteasome regulatory subunit 7 isoform 2
NM_002803.4 NP_002794.1 26S proteasome regulatory subunit 7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables proteasome-activating activity IDA
IDA: Inferred from direct assay
9295362 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
9295362 GOA
Cellular Component GO Annotation Evidence References Source
part of proteasome complex IDA
IDA: Inferred from direct assay
9295362 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

26S proteasome regulatory subunit 7

  • 26S protease regulatory subunit 7

PSMC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PSMC2 P35998 PSMC1 Homo sapiens P62191
Anti Tag CoIP
35271311
Intra
PSMC2 P35998 PSMC1 Homo sapiens P62191
Anti Tag CoIP
22901813
Intra
PSMC2 P35998 PSMC1 Homo sapiens P62191
Anti Tag CoIP
33961781
Intra
PSMC2 P35998 PSMC1 Homo sapiens P62191
Anti Tag CoIP
28514442
Intra
PSMC2 P35998 PSMD2 Homo sapiens Q13200
Anti Tag CoIP
22901813
Intra
PSMC2 P35998 PSMD2 Homo sapiens Q13200
Anti Tag CoIP
35271311
Intra
PSMC2 P35998 PSMD2 Homo sapiens Q13200
Validated Y2H
32296183
Intra
PSMC2 P35998 PSMD2 Homo sapiens Q13200
Anti Tag CoIP
33961781
Intra
PSMC2 P35998 PSMC5 Homo sapiens P62195
Anti Tag CoIP
22901813
Intra
PSMC2 P35998 PSMC5 Homo sapiens P62195
Anti Tag CoIP
35271311
Intra
PSMC2 P35998 PSMD4 Homo sapiens P55036
Anti Tag CoIP
35271311
Intra
PSMC2 P35998 PSMD5 Homo sapiens Q16401
Validated Y2H
27107012
Intra
PSMC2 P35998 PSMD5 Homo sapiens Q16401
Y2H Array
31515488
Intra
PSMC2 P35998 PSMD5 Homo sapiens Q16401
Validated Y2H
32296183
Intra
PSMC2 P35998 PSMD5 Homo sapiens Q16401
BFG-2H
27107012
Intra
PSMC2 P35998 PSMD5 Homo sapiens Q16401
Anti Tag CoIP
33961781
Intra
PSMC2 P35998 PSMD5 Homo sapiens Q16401
Y2H Pooling
16189514
Intra
PSMC2 P35998 RAD23B Homo sapiens P54727
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinal Melanoma

  • Malignant Retinal Melanoma

  • Malignant Melanoma Of Retina
Amyotrophic Lateral Sclerosis Type 15

  • Amyotrophic Lateral Sclerosis 15, With Or Without Frontotemporal Dementia

  • Als15

  • Amyotrophic Lateral Sclerosis 15
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11311 PSMC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PSMC2 RGD RGD:3428
Canis familiaris PSMC2 VGNC VGNC:45102
Felis catus PSMC2 VGNC VGNC:69112
Macaca mulatta PSMC2 VGNC VGNC:108432
Mus musculus PSMC2 MGD MGI:109555
Bos taurus PSMC2 VGNC VGNC:33455
Others PSMC2 NCBI