2. Gene
  3. PSMD5 - proteasome 26S subunit, non-ATPase 5 Gene

PSMD5 - proteasome 26S subunit, non-ATPase 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as S5B

Gene ID: 5711 | Gene type: protein coding

About PSMD5

Cytogenetic location: 9q33.2 Genomic coordinates (GRCh38): 9:120,816,053-120,842,922 (from NCBI)

This gene has 8 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in urinary bladder (RPKM 4.7), adrenal (RPKM 4.2) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a non-ATPase subunit of the 19S regulator base that functions as a chaperone protein during 26S Proteasome assembly. [provided by RefSeq, Jul 2012]

PSMD5 Products(2)

mRNA Protein Name
NM_001270427.2 NP_001257356.1 26S proteasome non-ATPase regulatory subunit 5 isoform 2
NM_005047.4 NP_005038.1 26S proteasome non-ATPase regulatory subunit 5 isoform 1

PSMD5 Protein Structure

Proteasom_PSMB

Proteasom_PSMB: Proteasome non-ATPase 26S subunit (1 - 504)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
Protein Preferred Names Protein Names

26S proteasome non-ATPase regulatory subunit 5

26S protease subunit S5 basic

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11326 PSMD5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PSMD5 VGNC VGNC:69125
Mus musculus PSMD5 MGD MGI:1914248
Bos taurus PSMD5 VGNC VGNC:33469
Macaca mulatta PSMD5 VGNC VGNC:76453
Rattus norvegicus PSMD5 RGD RGD:1308434