CASTOR1 - cytosolic arginine sensor for mTORC1 subunit 1 Gene

Also Known as GATSL3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 652968

About CASTOR1

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,285,117-30,289,505 (from NCBI)

This gene has 14 transcripts (splice variants), 191 orthologues and 1 paralogue. Broad expression in esophagus (RPKM 13.7), placenta (RPKM 8.5) and 22 other tissues.

Summary

Enables arginine binding activity and identical protein binding activity. Involved in cellular response to L-arginine and negative regulation of TORC1 signaling. Located in cytosol. Colocalizes with GATOR2 complex. [provided by Alliance of Genome Resources, Apr 2022]

CASTOR1 Products (1)

mRNA Protein Name
NM_001037666.3 NP_001032755.1 cytosolic arginine sensor for mTORC1 subunit 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arginine binding IDA
IDA: Inferred from direct assay
26972053 GOA
enables identical protein binding IDA
IDA: Inferred from direct assay
26972053 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables molecular sensor activity IDA
IDA: Inferred from direct assay
26972053 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein sequestering activity IDA
IDA: Inferred from direct assay
33594058 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to L-arginine IDA
IDA: Inferred from direct assay
26972053 GOA
involved in cellular response to L-arginine IMP
IMP: Inferred from mutant phenotype
26972053 GOA
involved in cellular response to amino acid starvation IDA
IDA: Inferred from direct assay
26972053 GOA
involved in negative regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
26972053 GOA
involved in negative regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
26972053 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
26972053 GOA
Cellular Component GO Annotation Evidence References Source
part of GATOR2 complex IDA
IDA: Inferred from direct assay
26972053 GOA
located in cytosol IDA
IDA: Inferred from direct assay
26972053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASTOR1 Protein Structure

ACT_7

ACT_7: ACT domain (72 - 138)

ACT_7

ACT_7: ACT domain (260 - 321)

  • 0
  • 100
  • 200
  • 300
  • 329 a.a.
Protein Preferred Names Protein Names

cytosolic arginine sensor for mTORC1 subunit 1

  • GATS protein like 3

CASTOR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CASTOR1 Q8WTX7 ZC2HC1A Homo sapiens Q96GY0
Anti Tag CoIP
33961781
Intra
CASTOR1 Q8WTX7 ZC2HC1A Homo sapiens Q96GY0
Anti Tag CoIP
28514442
Intra
CASTOR1 Q8WTX7 CASTOR2 Homo sapiens A6NHX0
Anti Tag CoIP
26972053
Intra
CASTOR1 Q8WTX7 CASTOR1 Homo sapiens Q8WTX7
Anti Tag CoIP
26972053
Intra
CASTOR1 Q8WTX7 ZC2HC1A Homo sapiens Q96GY0
Validated Y2H
25416956
Intra
CASTOR1 Q8WTX7 ZC2HC1A Homo sapiens Q96GY0
Y2H Prey Pooling
32296183
Intra
CASTOR1 Q8WTX7 CASTOR1 Homo sapiens Q8WTX7
Y2H Prey Pooling
32296183
Intra
CASTOR1 Q8WTX7 ZC2HC1A Homo sapiens Q96GY0
Validated Y2H
32296183
Intra
CASTOR1 Q8WTX7 CASTOR1 Homo sapiens Q8WTX7
Validated Y2H
32296183
Intra
CASTOR1 Q8WTX7 CASTOR1 Homo sapiens Q8WTX7
Y2H Array
25416956
Intra
CASTOR1 Q8WTX7 ZC2HC1A Homo sapiens Q96GY0
Y2H Array
32296183
Intra
CASTOR1 Q8WTX7 CASTOR1 Homo sapiens Q8WTX7
Y2H Array
32296183
Intra
CASTOR1 Q8WTX7 TMA16 Homo sapiens Q96EY4
Y2H Prey Pooling
32296183
Intra
CASTOR1 Q8WTX7 TMA16 Homo sapiens Q96EY4
Validated Y2H
32296183
Intra
CASTOR1 Q8WTX7 TMA16 Homo sapiens Q96EY4
Y2H Array
32296183
Intra
CASTOR1 Q8WTX7 CASTOR2 Homo sapiens A6NHX0
Anti Tag CoIP
33961781
Intra
CASTOR1 Q8WTX7 CASTOR2 Homo sapiens A6NHX0
Anti Tag CoIP
28514442
Intra
CASTOR1 Q8WTX7 ZC2HC1B Homo sapiens Q5TFG8
Y2H Prey Pooling
32296183
Intra
CASTOR1 Q8WTX7 ZC2HC1B Homo sapiens Q5TFG8
Y2H Array
32296183
Intra
CASTOR1 Q8WTX7 WDR59 Homo sapiens Q6PJI9
Anti Tag CoIP
33961781
Intra
CASTOR1 Q8WTX7 WDR59 Homo sapiens Q6PJI9
Anti Tag CoIP
28514442
Intra
CASTOR1 Q8WTX7 WDR59 Homo sapiens Q6PJI9
Anti Tag CoIP
26972053
Intra
CASTOR1 Q8WTX7 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
33961781
Intra
CASTOR1 Q8WTX7 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
28514442
Intra
CASTOR1 Q8WTX7 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
26972053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-176166 PD-M6 98.17% Unkown
HY-RS01979 CASTOR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19836 Castor1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26333 Castor1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CASTOR1 VGNC VGNC:38743
Bos taurus CASTOR1 VGNC VGNC:26791
Mus musculus CASTOR1 MGD MGI:1919212
Rattus norvegicus CASTOR1 RGD RGD:1304774
Felis catus CASTOR1 VGNC VGNC:80429
Others CASTOR1 NCBI