CASTOR2 - cytosolic arginine sensor for mTORC1 subunit 2 Gene

Also Known as GATSL1; GATSL2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 729438

About CASTOR2

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:74,964,705-75,031,528 (from NCBI)

This gene has 2 transcripts (splice variants), 202 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 6.4), ovary (RPKM 2.5) and 24 other tissues.

Summary

Enables identical protein binding activity. Involved in negative regulation of TORC1 signaling. Located in cytosol. Colocalizes with GATOR2 complex. [provided by Alliance of Genome Resources, Apr 2022]

CASTOR2 Products (1)

mRNA	Protein	Name
NM_001145064.3	NP_001138536.1	cytosolic arginine sensor for mTORC1 subunit 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables arginine binding	IDA IDA: Inferred from direct assay	26972053	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	26972053	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	26972053	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26972053	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	26972053	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of GATOR2 complex	IDA IDA: Inferred from direct assay	26972053	GOA
located in cytosol	IDA IDA: Inferred from direct assay	26972053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASTOR2 Protein Structure

ACT_7

0
100
200
300
329 a.a.

Protein Preferred Names	Protein Names
cytosolic arginine sensor for mTORC1 subunit 2	GATS protein like 2

CASTOR2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CASTOR2	A6NHX0	CASTOR1	Homo sapiens	Q8WTX7	Anti Tag CoIP	26972053
Intra	CASTOR2	A6NHX0	CASTOR2	Homo sapiens	A6NHX0	Anti Tag CoIP	26972053
Intra	CASTOR2	A6NHX0	MIOS	Homo sapiens	Q9NXC5	Anti Tag CoIP	26972053
Intra	CASTOR2	A6NHX0	WDR24	Homo sapiens	Q96S15	Anti Tag CoIP	26972053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinal Cord Glioma	Glial Tumor Of Spinal Cord Glial Neoplasm Spinal Cord Glioma Of Spinal Cord
Spinal Cancer	Spinal Cord Neoplasm Spinal Cord Neoplasms Spinal Neoplasms Intraspinal Tumor Malignant Tumor Of The Spinal Cord Spinal Cord Cancer Spinal Neoplasm Tumor Of The Spinal Cord Tumors Spinal Cord Intraspinal Neoplasm Spinal Cord--Cancer
Williams-Beuren Syndrome	Williams Syndrome WBS Wms Deletion 7q11.23 Monosomy 7q11.23 Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb Fanconi Schlesinger Syndrome Beuren Syndrome Elfin Facies Syndrome Elfin Facies With Hypercalcemia Hypercalcemia-Supravalvar Aortic Stenosis Ws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01980	CASTOR2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CASTOR2	MGD	MGI:1933384
Rattus norvegicus	CASTOR2	RGD	RGD:1304672