VEGFR-2/P-gp-IN-2

VEGFR-2/P-gp-IN-2 (Compound 5N) (0.78125-100 μM; 48 h) exhibits potent antiproliferative activity against HeLa, CaSki, SiHa, and HeLa/DDP cell lines with an SI of 53.0^[1].
VEGFR-2/P-gp-IN-2 (5 μM; 1 h) strongly inhibits VEGFR-2 kinase activity in cell-free assays with an IC₅₀ of 126.4 nM^[1].
VEGFR-2/P-gp-IN-2 (1-4 μM; 24 h) effectively blocks VEGFR-2 phosphorylation in HeLa and HeLa/DDP cells in a concentration-dependent manner^[1].
VEGFR-2/P-gp-IN-2 (1-4 μM) effectively inhibits endothelial tube formation in HUVECs in a concentration-dependent manner, demonstrating potent anti-angiogenic potential^[1].
VEGFR-2/P-gp-IN-2 (1-4 μM; 24 h) effectively blocks cell cycle progression at the G1 checkpoint in a concentration-dependent manner in HeLa and HeLa/DDP cells^[1].
VEGFR-2/P-gp-IN-2 (1-4 μM; 24 h) inhibits the proliferation of HeLa and HeLa/DDP cells by triggering robust apoptosis in a concentration-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.