Wnt/β-catenin-IN-1
Wnt/β-catenin-in-1 (compounds 17) is a Wnt/β-catenin signaling pathway inhibitor. Wnt/β-catenin-IN-1 can induce apoptosis of colon cancer cells, has broad-spectrum anticancer activity, and can be used for the reseach of a variety of solid tumors.
For research use only. We do not sell to patients.
- Formula: C26H25NO7
- Molecular Weight:463.48
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Wnt/β-catenin-IN-1 (compounds 17) (10 μM, 48 h) has broad-spectrum anticancer activity, with an average growth inhibition rate of 81.9% against 52 tumor cell lines in the trial[1].
Wnt/β-catenin-IN-1 (compounds 17) (10 μM, 48 h) is less cytotoxic to normal human cell lines (CCD841, MRC5) and is somewhat selective to cancer cells[1].
Wnt/β-catenin-IN-1 (compounds 17) (0/0.5/1/2 μM, 24 h/48 h) dose-dependently triggers cell cycle arrest and increases the population of HCT116 colon cancer cells in G2/M cell cycle phase[1].
Wnt/β-catenin-IN-1 (compounds 17) (0/0.5/1/2 μM, 24 h) is dose-dependent in reducing CDK8 level in HCT colorectal cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HCT116, HCT15, HT29, KM12, SW620, KM12, COLO205, HCC2998, CCD841, MRC5, et al.
-
Concentration:0.05 μM
-
Incubation Time:48 h
-
Result:Showed broad-spectrum anticancer activity, less toxicity to normal cells, and certain selectivity to cancer cells.
-
Cell Line:HCT116, HCT15, HT29, KM12, SW620, KM12, COLO205, HCC2998, CCD841, MRC5, et al.
-
Concentration:0.05 μM
-
Incubation Time:24 h
-
Result:Triggered G2/M cell cycle arrest by activating the p53-p21 pathway.
Chemical Information
-
Molecular Weight 463.48
-
Formula C26H25NO7
-
SMILES
COC1=CC=C(C=C1)C(NC2=CC(C3CC(C4=C(C(OC)=C(C=C4O3)OC)OC)=O)=CC=C2)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Wnt/β-catenin-IN-1 Related Classifications
HY-157990 Related Classifications
Powered by Bioz