2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. XPC-5462

XPC-5462 is a selective NaV1.6/1.2 inhibitor, with an IC50 of 0.0103 μM against hNaV1.6, 0.0137 μM against mNaV1.6, and 0.0109 μM against hNaV1.2. XPC-5462 significantly reduces epileptiform discharges. XPC-5462 is applicable for epilepsy-related research.

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XPC-5462

XPC-5462 Estructura química

No. CAS : 2230145-14-7

Tamaño Precio Stock Cantidad
5 mg En stock
10 mg En stock
25 mg Obtener un presupuesto
50 mg Obtener un presupuesto
100 mg Obtener un presupuesto
200 mg   Obtener un presupuesto  
500 mg   Obtener un presupuesto  

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XPC-5462 Related Antibodies

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Descripciòn

XPC-5462 is a selective NaV1.6/1.2 inhibitor, with an IC50 of 0.0103 μM against hNaV1.6, 0.0137 μM against mNaV1.6, and 0.0109 μM against hNaV1.2. XPC-5462 significantly reduces epileptiform discharges. XPC-5462 is applicable for epilepsy-related research[1].

IC50 & Target[1]

hNaV1.2

0.0109 μM (IC50)

hNav1.6

0.0103 μM (IC50)

mNaV1.6

0.0137 μM (IC50)

In Vitro

XPC-5462 potently and equipotently inhibits human NaV1.2 and NaV1.6 channels (IC50 = 0.0109 μM and IC50 = 0.0103 μM[1]).

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

XPC-5462 Related Antibodies
Peso molecular

486.51

Fòrmula

C20H18F4N4O2S2
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=S(NC1=CSC=N1)(C2=C(C=C(C=C2F)NCC3=C(C(F)=CC=C3F)CN4CCC4)F)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (205.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0555 mL 10.2773 mL 20.5546 mL
5 mM 0.4111 mL 2.0555 mL 4.1109 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (5.14 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (5.14 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación

Purity: 99.65%

SDS (251 KB)

COA (250 KB) HNMR (143 KB) LCMS (102 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0555 mL 10.2773 mL 20.5546 mL 51.3864 mL
5 mM 0.4111 mL 2.0555 mL 4.1109 mL 10.2773 mL
10 mM 0.2055 mL 1.0277 mL 2.0555 mL 5.1386 mL
15 mM 0.1370 mL 0.6852 mL 1.3703 mL 3.4258 mL
20 mM 0.1028 mL 0.5139 mL 1.0277 mL 2.5693 mL
25 mM 0.0822 mL 0.4111 mL 0.8222 mL 2.0555 mL
30 mM 0.0685 mL 0.3426 mL 0.6852 mL 1.7129 mL
40 mM 0.0514 mL 0.2569 mL 0.5139 mL 1.2847 mL
50 mM 0.0411 mL 0.2055 mL 0.4111 mL 1.0277 mL
60 mM 0.0343 mL 0.1713 mL 0.3426 mL 0.8564 mL
80 mM 0.0257 mL 0.1285 mL 0.2569 mL 0.6423 mL
100 mM 0.0206 mL 0.1028 mL 0.2055 mL 0.5139 mL
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XPC-5462 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XPC-54622230145-14-7XPC5462XPC 5462Sodium ChannelNa channelsNa+ channelsmouse NaV1.6NaV1.1 channelsvoltage-sensing domain IVvoltage-gated sodium channelhuman NaV1.2epilepsyhuman NaV1.6CA1 pyramidal neuronepileptiform activityFreeStyle 293F cellsInhibitorinhibitorinhibit

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Nombre del producto:
XPC-5462
Cat. No.:
HY-157786
Cantidad:
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