Z3405279217
Z3405279217 is an inhibitor of ALDH1A3 and ALDH1A1, with an IC50 value of 12.9 μM against ALDH1A3. Z3405279217 can be used in studies of non-small cell lung cancer and glioblastoma.
For research use only. We do not sell to patients.
- CAS No.: 2305402-77-9
- Formula: C10H8N2OS2
- Molecular Weight:236.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
ALDH1A3 12.9 μM (IC50) |
ALDH1A1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | EC50 |
16.6 μM
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Reduction of cell viability in human non-small cell lung cancer A549 cells after 24 h incubation.
Reduction of cell viability in human non-small cell lung cancer A549 cells after 24 h incubation.
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2026.07.14.738401v1.abstract |
| A549 | EC50 |
16.4 μM
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Reduction of cell viability in human non-small cell lung cancer A549 cells after 48 h incubation.
Reduction of cell viability in human non-small cell lung cancer A549 cells after 48 h incubation.
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2026.07.14.738401v1.abstract |
| A549 | EC50 |
20.3 μM
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Reduction of cell viability in human non-small cell lung cancer A549 cells after 72 h incubation.
Reduction of cell viability in human non-small cell lung cancer A549 cells after 72 h incubation.
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2026.07.14.738401v1.abstract |
| A 172 | EC50 |
17.7 μM
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Reduction of cell viability in human glioblastoma A172 cells after 24 h incubation.
Reduction of cell viability in human glioblastoma A172 cells after 24 h incubation.
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2026.07.14.738401v1.abstract |
| A 172 | EC50 |
16.6 μM
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Reduction of cell viability in human glioblastoma A172 cells after 48 h incubation.
Reduction of cell viability in human glioblastoma A172 cells after 48 h incubation.
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2026.07.14.738401v1.abstract |
| A 172 | EC50 |
12.3 μM
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Reduction of cell viability in human glioblastoma A172 cells after 72 h incubation.
Reduction of cell viability in human glioblastoma A172 cells after 72 h incubation.
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2026.07.14.738401v1.abstract |
In Vitro
Z3405279217 (100 μM) potently and selectively inhibits the esterase activity of recombinant ALDH1A3, with an IC50 of 12.9 μM[1].
Z3405279217 is a time-dependent covalent inhibitor of the dehydrogenase activity of recombinant ALDH1A3 and ALDH1A1, with kinact/Ki values of 6,200 M-1·min-1 and 11,400 M-1·min-1, respectively[1].
Z3405279217 (20 min) potently inhibits endogenous ALDH activity in non-small cell lung cancer A549 cell extracts and glioblastoma A172 cell extracts, with IC50 values of 0.135 μM and 1.93 μM, respectively[1].
Z3405279217 (24-72 h) reduces the viability of non-small cell lung cancer A549 cells and glioblastoma A172 cells, with EC50 values ranging from 12.3 μM to 20.3 μM under 24-72 h treatment conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human non-small cell lung cancer A549 cells, human glioblastoma A172 cells
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Concentration:12.3 μM, 16.4 μM, 16.6 μM, 17.7 μM, 20.3 μM (EC50 values)
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Incubation Time:24 h, 48 h, 72 h
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Result:Reduced viability of A549 cells with EC50 values of 16.6 μM (24 h), 16.4 μM (48 h), and 20.3 μM (72 h).
Reduced viability of A172 cells with EC50 values of 17.7 μM (24 h), 16.6 μM (48 h), and 12.3 μM (72 h).
Chemical Information
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CAS No. 2305402-77-9
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Molecular Weight 236.31
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Formula C10H8N2OS2
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SMILES
C=CC(NC1=NC(C2=CC=CS2)=CS1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Z3405279217 Related Classifications
HY-187703 Related Classifications
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