1,2-Didecanoyl PC
Based on 1 Customer Validation
1,2-Didecanoyl PC (1,2-Didecanoyl-sn-glycero-3-phosphocholine) is an orally effective medium-chain saturated phospholipid with well-defined P-gp inhibitory activity and membrane-modulating functions. As a functional excipient/absorption enhancer, 1,2-Didecanoyl PC is particularly suitable for oral formulations of P-gp substrates (e.g., Ritonavir (HY-90001)).
For research use only. We do not sell to patients.
- Purity : 99.71%
- CAS No.: 3436-44-0
- Formula: C28H56NO8P
- Molecular Weight:565.72
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-113424A
1,2-Dioleoyl-sn-glycero-3-phosphocholine -
HY-W040193
DSPC -
HY-109541
Colfosceril miristate -
HY-112005
DOPE -
HY-130462
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC -
HY-130463
POPG sodium -
HY-130462R
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC (Standard) -
HY-W040193GL
DSPC (GMP Like) -
HY-142988
1-Stearoyl-2-myristoyl-sn-glycero-3-PC -
HY-141571
DOPG sodium -
HY-W322225
1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine -
HY-125940
DPPG
Biological Activity
Description
In Vitro
1,2-Didecanoyl PC reduces P-glycoprotein activity via a non-membrane fluidization mechanism and enhances the permeability of P-glycoprotein substrates across intestinal cell layers[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3436-44-0
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Appearance Solid
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Molecular Weight 565.72
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Formula C28H56NO8P
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Color White to off-white
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SMILES
C[N+](C)(C)CCOP(OC[C@H](OC(CCCCCCCCC)=O)COC(CCCCCCCCC)=O)([O-])=O
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Synonyms
1,2-Didecanoyl-sn-glycero-3-phosphocholine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (88.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (645 KB)
- English - EN (645 KB)
- Français - FR (645 KB)
- Deutsch - DE (645 KB)
- Norwegian - NO (645 KB)
- Español - ES (645 KB)
- Swedish - SV (645 KB)
- Italian - IT (645 KB)
- Korean - KR (645 KB)
- Portuguese - PT (645 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7677 mL | 8.8383 mL | 17.6766 mL | 44.1915 mL |
| 5 mM | 0.3535 mL | 1.7677 mL | 3.5353 mL | 8.8383 mL | |
| 10 mM | 0.1768 mL | 0.8838 mL | 1.7677 mL | 4.4191 mL | |
| 15 mM | 0.1178 mL | 0.5892 mL | 1.1784 mL | 2.9461 mL | |
| 20 mM | 0.0884 mL | 0.4419 mL | 0.8838 mL | 2.2096 mL | |
| 25 mM | 0.0707 mL | 0.3535 mL | 0.7071 mL | 1.7677 mL | |
| 30 mM | 0.0589 mL | 0.2946 mL | 0.5892 mL | 1.4730 mL | |
| 40 mM | 0.0442 mL | 0.2210 mL | 0.4419 mL | 1.1048 mL | |
| 50 mM | 0.0354 mL | 0.1768 mL | 0.3535 mL | 0.8838 mL | |
| 60 mM | 0.0295 mL | 0.1473 mL | 0.2946 mL | 0.7365 mL | |
| 80 mM | 0.0221 mL | 0.1105 mL | 0.2210 mL | 0.5524 mL |
1,2-Didecanoyl PC Related Classifications
HY-131640 Related Classifications
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