1,3,4-Thiadiazol-2-amine
Based on 1 Customer Validation
1,3,4-Thiadiazol-2-amine is a 1,3,4-thiadiazole antitumor agent with the potential to penetrate the blood-brain barrier. 1,3,4-Thiadiazol-2-amine can induce hyperuricemia, and this effect is blocked by Nicotinamide (HY-B0150). 1,3,4-Thiadiazol-2-amine supports the simultaneous administration of Allopurinol (HY-B0219), and their combined use prevents hyperuricemia without reducing antitumor activity.\n1,3,4-Thiadiazol-2-amine is a condensation precursor for the synthesis of antibacterial Schiff bases and their Co/Cu/Ni/Zn (II) complexes. 1,3,4-Thiadiazol-2-amine is used in research related to tumors and bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 4005-51-0
- Formula: C2H3N3S
- Molecular Weight:101.13
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Storage:
RT, protect from light.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Ehrlich | ED50 |
56 μg/cm3
Compound: 1
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In vitro antitumor activity against Mus musculus (mouse) Ehrlich ascites cell assessed as dead tumor cells by trypan blue exclusion test
In vitro antitumor activity against Mus musculus (mouse) Ehrlich ascites cell assessed as dead tumor cells by trypan blue exclusion test
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10.1007/s00044-012-0336-z |
In Vitro
1,3,4-Thiadiazol-2-amine (12-100 μg/mL; 30 min) exhibits a plasma protein binding rate of less than 7% in canine plasma and 10% in human plasma, with its AT-albumin binding constant being 1.3×102 per mole for canine and 2.5×102 per mole for human[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
| Species | Dose | Route | T1/2α | T1/2β | Vd | CLtotal |
|---|---|---|---|---|---|---|
| Dog[1] | 10 mg/kg | i.v. | 4 min | 13 h | 319 mL/kg | 0.6 mL/min/kg |
| Dog[1] | 25 mg/kg | i.v. | 5 min | 10 h | 293 mL/kg | 0.8 mL/min/kg |
| Dog[1] | 25 (co-administered with Allopurinol 60 mg/kg) mg/kg | i.v. | 5.3 min | 13 h | 450 mL/kg | 0.7 mL/min/kg |
| Dog[1] | 25 (co-administered with Allopurinol 30 mg/kg) mg/kg | i.v. | 4.1 min | 13 h | 527 mL/kg | 0.8 mL/min/kg |
Chemical Information
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CAS No. 4005-51-0
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Appearance Solid
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Molecular Weight 101.13
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Formula C2H3N3S
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SMILES
NC1=NN=CS1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
RT, protect from light
In solvent -80°C 1 year -20°C 6 months
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
1,3,4-Thiadiazol-2-amine Related Classifications
HY-W018798 Related Classifications
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