4005-51-0
Chemical Structure
1,3,4-Thiadiazol-2-amine
- CAS No.: 4005-51-0
- Formula:C2H3N3S
- Molecular Weight:101.13
IUPAC Name: 1,3,4-thiadiazol-2-amine
InChIKey: QUKGLNCXGVWCJX-UHFFFAOYSA-N
SMILES: NC1=NN=CS1
Biological Activity: 1,3,4-Thiadiazol-2-amine is a 1,3,4-thiadiazole antitumor agent with the potential to penetrate the blood-brain barrier. 1,3,4-Thiadiazol-2-amine can induce hyperuricemia, and this effect is blocked by Nicotinamide (HY-B0150). 1,3,4-Thiadiazol-2-amine supports the simultaneous administration of Allopurinol (HY-B0219), and their combined use prevents hyperuricemia without reducing antitumor activity.\n1,3,4-Thiadiazol-2-amine is a condensation precursor for the synthesis of antibacterial Schiff bases and their Co/Cu/Ni/Zn (II) complexes. 1,3,4-Thiadiazol-2-amine is used in research related to tumors and bacterial infections[1][2].
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1,3,4-Thiadiazol-2-amine | 1,3,4-Thiadiazol-2-amine is a 1,3,4-thiadiazole antitumor agent with the potential to penetrate the blood-brain barrier. 1,3,4-Thiadiazol-2-amine can induce hyperuricemia, and this effect is blocked by Nicotinamide (HY-B0150). 1,3,4-Thiadiazol-2-amine supports the simultaneous administration of Allopurinol (HY-B0219), and their combined use prevents hyperuricemia without reducing antitumor activity.\n1,3,4-Thiadiazol-2-amine is a condensation precursor for the synthesis of antibacterial Schiff bases and their Co/Cu/Ni/Zn (II) complexes. 1,3,4-Thiadiazol-2-amine is used in research related to tumors and bacterial infections. | |||||||||||||||||||||
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References
- [1]. Lu K, et al. The pharmacologic fate of the antitumor agent 2-amino-1,3,4-thiadiazole in the dog. Cancer chemotherapy and pharmacology. 1980;4(4):275-9.
- [2]. Chohan Z H, Jaffery M F, Supuran C T. antibacterial Co (II), Cu (II), Ni (II) and Zn (II) complexes of thiadiazoles Schiff bases[J]. Metal‐Based Drugs, 2001, 8(2): 95-101.
