1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. 1,4-Anthraquinone

1,4-Anthraquinone is a potent anticancer agent. 1,4-Anthraquinone blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of cancer cells. 1,4-Anthraquinone can be used to research anti-leukemia.

For research use only. We do not sell to patients.

1,4-Anthraquinone Chemical Structure

1,4-Anthraquinone Chemical Structure

CAS No. : 635-12-1

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Description

1,4-Anthraquinone is a potent anticancer agent. 1,4-Anthraquinone blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation, and decreases the growth and viability of cancer cells. 1,4-Anthraquinone can be used to research anti-leukemia[1].

IC50 & Target

DNA/RNA synthesis[1]

In Vitro

1,4-Anthraquinone (2.62 nM-1.6 μM; 4 days) induces significant antiproliferative and cytotoxic effects in L1210 cells after 4 days at 6.55 nM; inhibits cell viability with IC50s of 100 nM at day 2 and 25 nM at day 4[1].
1,4-Anthraquinone (40.96 nM-25 μM; 30 min; L1210 cells) inhibits nucleoside transport by 71 and 92% and DNA synthesis by 84 and 96% at 4 and 10 μM, respectively, and are both irreversible upon drug removal[1].
1,4-Anthraquinone (0.1024-25 μM; 3 h) inhibits the rates of RNA and protein syntheses (IC50 = 2 μM) in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: L1210 cells
Concentration: 2.62 nM-1.6 μM
Incubation Time: 4 days
Result: Induced significant antiproliferative and cytotoxic effects after 4 days at 6.55 nM.

Cell Viability Assay[1]

Cell Line: L1210 cells
Concentration: 2.62 nM-1.6 μM
Incubation Time: 4 days
Result: Inhibited cell viability with IC50s of 100 nM at day 2 and 25 nM at day 4.
Molecular Weight

208.21

Formula

C14H8O2

CAS No.
Appearance

Solid

Color

Yellow to brown

SMILES

O=C1C=CC(C2=C1C=C3C=CC=CC3=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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1,4-Anthraquinone Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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1,4-Anthraquinone
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HY-W077242
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