2. PROTAC
  3. Ligands for E3 Ligase
  4. 2-Methoxyphenyl dihydrouracil

2-Methoxyphenyl dihydrouracil (Compound 13) is a CRBN ligand, and can be used for synthesis of PROTACs.

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2-Methoxyphenyl dihydrouracil

2-Methoxyphenyl dihydrouracil Chemical Structure

CAS No. : 2377643-33-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
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2-Methoxyphenyl dihydrouracil Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

2-Methoxyphenyl dihydrouracil (Compound 13) is a CRBN ligand, and can be used for synthesis of PROTACs[1].

IC50 & Target[1]

Cereblon

 

Molecular Weight

264.23

Formula

C12H12N2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C1=CC=C(OC)C(N(C(N2)=O)CCC2=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (126.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7846 mL 18.9229 mL 37.8458 mL
5 mM 0.7569 mL 3.7846 mL 7.5692 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.0%

SDS (393 KB)

COA (249 KB) HNMR (112 KB) MS (150 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7846 mL 18.9229 mL 37.8458 mL 94.6145 mL
5 mM 0.7569 mL 3.7846 mL 7.5692 mL 18.9229 mL
10 mM 0.3785 mL 1.8923 mL 3.7846 mL 9.4615 mL
15 mM 0.2523 mL 1.2615 mL 2.5231 mL 6.3076 mL
20 mM 0.1892 mL 0.9461 mL 1.8923 mL 4.7307 mL
25 mM 0.1514 mL 0.7569 mL 1.5138 mL 3.7846 mL
30 mM 0.1262 mL 0.6308 mL 1.2615 mL 3.1538 mL
40 mM 0.0946 mL 0.4731 mL 0.9461 mL 2.3654 mL
50 mM 0.0757 mL 0.3785 mL 0.7569 mL 1.8923 mL
60 mM 0.0631 mL 0.3154 mL 0.6308 mL 1.5769 mL
80 mM 0.0473 mL 0.2365 mL 0.4731 mL 1.1827 mL
100 mM 0.0378 mL 0.1892 mL 0.3785 mL 0.9461 mL
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2-Methoxyphenyl dihydrouracil Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Methoxyphenyl dihydrouracil2377643-33-7Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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