2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage
  3. Drug-Linker Conjugates for ADC Topoisomerase
  4. 2-MSP-5-HA-VA-PAB-Exatecan

2-MSP-5-HA-Val-Cit-PAB-Exatecan (A-24) is a drug-linker conjugate for ADC. 2-MSP-5-HA-Val-Cit-PAB-Exatecan consists of Exatecan (HY-13631) and a linker. 2-MSP-5-HA-Val-Cit-PAB-Exatecan can be used for synthesis of ADCs.

For research use only. We do not sell to patients.

2-MSP-5-HA-VA-PAB-Exatecan

2-MSP-5-HA-VA-PAB-Exatecan Chemical Structure

CAS No. : 2878440-72-1

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Based on 1 publication(s) in Google Scholar

2-MSP-5-HA-VA-PAB-Exatecan Related Antibodies

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Description

2-MSP-5-HA-Val-Cit-PAB-Exatecan (A-24) is a drug-linker conjugate for ADC. 2-MSP-5-HA-Val-Cit-PAB-Exatecan consists of Exatecan (HY-13631) and a linker. 2-MSP-5-HA-Val-Cit-PAB-Exatecan can be used for synthesis of ADCs[1].

Molecular Weight

1005.08

Formula

C51H53FN8O11S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CS(C1=NC=C(C=N1)C#CCCCC(N[C@@H](C(C)C)C(N[C@@H](C)C(NC(C=C2)=CC=C2COC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O)=O)=O)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (99.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9949 mL 4.9747 mL 9.9495 mL
5 mM 0.1990 mL 0.9949 mL 1.9899 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9949 mL 4.9747 mL 9.9495 mL 24.8736 mL
5 mM 0.1990 mL 0.9949 mL 1.9899 mL 4.9747 mL
10 mM 0.0995 mL 0.4975 mL 0.9949 mL 2.4874 mL
15 mM 0.0663 mL 0.3316 mL 0.6633 mL 1.6582 mL
20 mM 0.0497 mL 0.2487 mL 0.4975 mL 1.2437 mL
25 mM 0.0398 mL 0.1990 mL 0.3980 mL 0.9949 mL
30 mM 0.0332 mL 0.1658 mL 0.3316 mL 0.8291 mL
40 mM 0.0249 mL 0.1244 mL 0.2487 mL 0.6218 mL
50 mM 0.0199 mL 0.0995 mL 0.1990 mL 0.4975 mL
60 mM 0.0166 mL 0.0829 mL 0.1658 mL 0.4146 mL
80 mM 0.0124 mL 0.0622 mL 0.1244 mL 0.3109 mL
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2-MSP-5-HA-VA-PAB-Exatecan Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-MSP-5-HA-VA-PAB-Exatecan2878440-72-1Drug-Linker Conjugates for ADCTopoisomeraseInhibitorinhibitorinhibit

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