1. Terpenoids and Glycosides
  2. 5,15-Diacetyl-3-benzoyllathyrol

5,15-Diacetyl-3-benzoyllathyrol (Synonyms: Euphorbia factor L3)

Cat. No.: HY-N0562 Purity: 98.85%
Handling Instructions

5,15-Diacetyl-3-benzoyllathyrol is one of the lathyrane diterpenoids, that has anti-cancer activity.

For research use only. We do not sell to patients.

5,15-Diacetyl-3-benzoyllathyrol Chemical Structure

5,15-Diacetyl-3-benzoyllathyrol Chemical Structure

CAS No. : 218916-52-0

Size Price Stock Quantity
1 mg USD 150 In-stock
Estimated Time of Arrival: December 31
5 mg USD 375 In-stock
Estimated Time of Arrival: December 31
10 mg USD 635 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

5,15-Diacetyl-3-benzoyllathyrol is one of the lathyrane diterpenoids, that has anti-cancer activity.

In Vitro

5,15-Diacetyl-3-benzoyllathyrol shows anticancer activity in vitro against lung cancer A549 cells and the IC50 values are 34.04±3.99 μM. Furthermore, 5,15-Diacetyl-3-benzoyllathyrol can induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

522.63

Formula

C31H38O7

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (191.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9134 mL 9.5670 mL 19.1340 mL
5 mM 0.3827 mL 1.9134 mL 3.8268 mL
10 mM 0.1913 mL 0.9567 mL 1.9134 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.78 mM); Clear solution

*All of the co-solvents are available by MCE.
References
Cell Assay
[1]

Cells are harvested during logarithmic growth phase and seeded in 96-well plates at a density of 1.5×104 cells/mL of final volume 190 μL/well. After incubation of 24 h, 10 μL EFL3 solution of full range concentrations is added to 96-well plates. After 68 h treatment, 10 μL MTT of 10 mM is added to each well for 4 h of maintaining at 37°C. Then, the supernatant is removed and the crystals are dissolved with 100 μL anhydrous DMSO each well. Subsequently, cell viability is measured by Model 550 Microplate reader at 540 nm and 655 nm as reference filter. Experiments are carried out at least thrice. The 50% inhibitory concentration (IC50) is defined as the anticancer agent concentration causing 50% reduction in cell viability and calculated from the cytotoxicity curves. Cell survival is calculated with the following formula: survival (%)=(mean experimental absorbance/mean control absorbance) × 100%.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Product Name:
5,15-Diacetyl-3-benzoyllathyrol
Cat. No.:
HY-N0562
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