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  3. AAI101

AAI101 

製品番号: HY-103095 純度: >98.0%
取扱説明書

AAI101 is an extended-spectrum β-lactamase inhibitor, against many resistant Gram-negative pathogens.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用としては使用しないように、十分ご注意ください。

AAI101 構造式

AAI101 構造式

CAS 番号 : 1001404-83-6

容量 価格(税別) 在庫状況 数量
10 mM * 1  mL in DMSO USD 145 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 132 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 192 在庫あり
Estimated Time of Arrival: December 31
25 mg USD 348 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 588 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 828 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

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製品説明

AAI101 is an extended-spectrum β-lactamase inhibitor, against many resistant Gram-negative pathogens.

体外実験

AAI101 shows potent activity against specific resistance phenotypes with MIC50 and MIC90 of 0.125 mg/L and 64 mg/L[1]. Cefepime-AAI101 MICs decreases with increasing concentrations of AAI101 (over the range from 1 to 16 mg/L) for most strains, demonstrating a concentration dependence of AAI101 on restoration of the antibacterial activity of the cephalosporin[1].

体内実験

In neutropenic animals, cefepime-AAI101 treatment results in reductions in bacterial density of ≥0.5 log10 CFU for 12 of the 20 strains tested and reductions of ≥1 log10 CFU for 6 of these. Increases in bacterial density are for only four strains, three of which have cefepime-AAI101 MICs of ≥64 mg/L, irrespective of the AAI101 concentration[2].

臨床実験
分子量

314.32

分子式

C₁₁H₁₄N₄O₅S

CAS 番号

1001404-83-6

SMILES

C[N+]1=NN(C[[email protected]@](S([[email protected]]2([H])C3)(=O)=O)(C)[[email protected]](C([O-])=O)N2C3=O)C=C1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶剤 & 溶解度
体外: 

DMSO : ≥ 113.3 mg/mL (360.46 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1815 mL 15.9074 mL 31.8147 mL
5 mM 0.6363 mL 3.1815 mL 6.3629 mL
10 mM 0.3181 mL 1.5907 mL 3.1815 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.62 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
参考文献
動物実験
[2]

The 20 Enterobacteriaceae strains are used to infect groups of three mice each. At 2 h after inoculation, mice are treated with humanized regimens of cefepime or cefepime-AAI101. All doses are administered as 0.2-mL subcutaneous injections. To serve as control animals, an additional group of mice is administered normal saline at the same volume and frequency and by the same route. Thighs from all animals are harvested at 24 h after initiation of therapy. The harvesting procedure for all study mice began with euthanasia by CO2 exposure, followed by cervical dislocation. After sacrifice, thighs are removed and homogenized individually in normal saline. For determinations of the numbers of CFU, serial dilutions of thigh homogenates are spread onto Trypticase soy agar with 5% sheep blood using a spiral plater. In addition to the aforementioned treatment and control groups, another group of three infected but untreated mice is harvested at the initiation of dosing and served as a 0-h control. Efficacy, expressed as the change in bacterial density, is determined by calculation of the change in the log10 number of CFU obtained in mice after 24 h of treatment from the densities observed in the 0-h control animals.

MCE はこれらの方法の精度を確認していません。 こちらは参照専用です。

参考文献

純度: >98.0%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AAI101AAI 101AAI-101BacterialInhibitorinhibitorinhibit

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製品名:
AAI101
製品番号:
HY-103095
数量:
MCE 日本正規代理店: