1. Anti-infection
  2. Bacterial
  3. Enmetazobactam

Enmetazobactam  (Synonyms: AAI101)

製品番号: HY-103095 純度: 95.11%
COA 取扱説明書

Enmetazobactam (AAI101) is an extended-spectrum β-lactamase inhibitor, against many resistant Gram-negative pathogens.


Enmetazobactam 構造式

Enmetazobactam 構造式

CAS 番号 : 1001404-83-6

容量 価格(税別) 在庫状況 数量
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 99 在庫あり
10 mM * 1 mL in DMSO USD 99 在庫あり
1 mg USD 42 在庫あり
5 mg USD 90 在庫あり
10 mg USD 150 在庫あり
50 mg USD 450 在庫あり
100 mg USD 650 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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Enmetazobactam (AAI101) is an extended-spectrum β-lactamase inhibitor, against many resistant Gram-negative pathogens.


Enmetazobactam shows potent activity against specific resistance phenotypes with MIC50 and MIC90 of 0.125 mg/L and 64 mg/L[1]. Cefepime-Enmetazobactam MICs decreases with increasing concentrations of Enmetazobactam (over the range from 1 to 16 mg/L) for most strains, demonstrating a concentration dependence of Enmetazobactam on restoration of the antibacterial activity of the cephalosporin[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.


In neutropenic animals, cefepime-Enmetazobactam treatment results in reductions in bacterial density of ≥0.5 log10 CFU for 12 of the 20 strains tested and reductions of ≥1 log10 CFU for 6 of these. Increases in bacterial density are for only four strains, three of which have cefepime-Enmetazobactam MICs of ≥64 mg/L, irrespective of the Enmetazobactam concentration[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.







CAS 番号



Room temperature in continental US; may vary elsewhere.


-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶剤 & 溶解度

DMSO : ≥ 113.3 mg/mL (360.46 mM)

*"≥" means soluble, but saturation unknown.

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1815 mL 15.9074 mL 31.8147 mL
5 mM 0.6363 mL 3.1815 mL 6.3629 mL
10 mM 0.3181 mL 1.5907 mL 3.1815 mL
*Please refer to the solubility information to select the appropriate solvent.
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (6.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (6.62 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (6.62 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).

The 20 Enterobacteriaceae strains are used to infect groups of three mice each. At 2 h after inoculation, mice are treated with humanized regimens of cefepime or cefepime-AAI101. All doses are administered as 0.2-mL subcutaneous injections. To serve as control animals, an additional group of mice is administered normal saline at the same volume and frequency and by the same route. Thighs from all animals are harvested at 24 h after initiation of therapy. The harvesting procedure for all study mice began with euthanasia by CO2 exposure, followed by cervical dislocation. After sacrifice, thighs are removed and homogenized individually in normal saline. For determinations of the numbers of CFU, serial dilutions of thigh homogenates are spread onto Trypticase soy agar with 5% sheep blood using a spiral plater. In addition to the aforementioned treatment and control groups, another group of three infected but untreated mice is harvested at the initiation of dosing and served as a 0-h control. Efficacy, expressed as the change in bacterial density, is determined by calculation of the change in the log10 number of CFU obtained in mice after 24 h of treatment from the densities observed in the 0-h control animals.

MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。

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Enmetazobactam Related Classifications

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