Riboflavin Tetrabutyrate
Based on 1 Customer Validation
Riboflavin Tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.
For research use only. We do not sell to patients.
- Purity: 98.11%
- CAS No.: 752-56-7
- Formula: C33H44N4O10
- Molecular Weight:656.72
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Riboflavin Tetrabutyrate inhibits oxygen uptake by lipid peroxidation. Riboflavin Tetrabutyrate is suppressive against both NADPH-coupled and ascorbate-induced microsomal lipid peroxidation. Riboflavin Tetrabutyrate seems to exhibit its antioxidative action at or after the hydrogen atom is abstracted as a free radical from an active methylene group of polyunsaturated fatty acids during the process of enzymic oxidation-reduction reaction[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 752-56-7
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Appearance Solid
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Molecular Weight 656.72
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Formula C33H44N4O10
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Color Yellow to orange
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SMILES
O=C(CCC)O[C@H]([C@H](OC(CCC)=O)[C@H](OC(CCC)=O)COC(CCC)=O)CN1C(C=C(C)C(C)=C2)=C2N=C(C(N3)=O)C1=NC3=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : ≥ 100 mg/mL (152.27 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
Rats: Riboflavin tetrabutyrate-14C (700 μg, corresponding to 400 μg of riboflavin; total radioactivity 2.19×105 cpm) is suspended in 0.2mL of soybean oil and given per os . In the case of injection, same amount of Riboflavin tetrabutyrate-14C is dissolved in 1mL of soybean oil and injected subcutaneously into the back of rat[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (282 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Tahara K, et al. Effect of riboflavin and riboflavin 2',3',4',5'-tetrabutyrate on rat liver microsomallipid peroxidation. J Nutr Sci Vitaminol (Tokyo). 1974;20(2):81-8. [Content Brief]
[2]. Okuno E, et al. Effect of chronic administration of riboflavin 2',3',4',5'-tetrabutyrate on the hepatic enzymes of fatty acid oxidation in the rat. J Nutr Sci Vitaminol (Tokyo). 1983 Dec;29(6):637-42. [Content Brief]
[3]. Yagi K, et al. Studies on fatty acid esters of flavins. VI. Incorporation of riboflavin part of riboflavin tetrabutyrate-2-14C into flavin nucleotides in the organs of rat. J Vitaminol (Kyoto). 1969 Jun 10;15(2):155-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5227 mL | 7.6136 mL | 15.2272 mL | 38.0680 mL |
| 5 mM | 0.3045 mL | 1.5227 mL | 3.0454 mL | 7.6136 mL | |
| 10 mM | 0.1523 mL | 0.7614 mL | 1.5227 mL | 3.8068 mL | |
| 15 mM | 0.1015 mL | 0.5076 mL | 1.0151 mL | 2.5379 mL | |
| 20 mM | 0.0761 mL | 0.3807 mL | 0.7614 mL | 1.9034 mL | |
| 25 mM | 0.0609 mL | 0.3045 mL | 0.6091 mL | 1.5227 mL | |
| 30 mM | 0.0508 mL | 0.2538 mL | 0.5076 mL | 1.2689 mL | |
| 40 mM | 0.0381 mL | 0.1903 mL | 0.3807 mL | 0.9517 mL | |
| 50 mM | 0.0305 mL | 0.1523 mL | 0.3045 mL | 0.7614 mL | |
| 60 mM | 0.0254 mL | 0.1269 mL | 0.2538 mL | 0.6345 mL | |
| 80 mM | 0.0190 mL | 0.0952 mL | 0.1903 mL | 0.4758 mL | |
| 100 mM | 0.0152 mL | 0.0761 mL | 0.1523 mL | 0.3807 mL |
Riboflavin Tetrabutyrate Related Classifications
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