2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Riboflavin Tetrabutyrate

Riboflavin Tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.

For research use only. We do not sell to patients.

Riboflavin Tetrabutyrate Chemical Structure

Riboflavin Tetrabutyrate Chemical Structure

CAS No. : 752-56-7

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Based on 1 publication(s) in Google Scholar

Riboflavin Tetrabutyrate Related Antibodies

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  • Biological Activity

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  • Purity & Documentation

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Description

Riboflavin Tetrabutyrate is a lipophilic flavin derivative with antioxidative and lipid peroxide-removing activity.

In Vitro

Riboflavin Tetrabutyrate inhibits oxygen uptake by lipid peroxidation. Riboflavin Tetrabutyrate is suppressive against both NADPH-coupled and ascorbate-induced microsomal lipid peroxidation. Riboflavin Tetrabutyrate seems to exhibit its antioxidative action at or after the hydrogen atom is abstracted as a free radical from an active methylene group of polyunsaturated fatty acids during the process of enzymic oxidation-reduction reaction[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Riboflavin Tetrabutyrate Related Antibodies
In Vivo

Riboflavin Tetrabutyrate might improve the metabolism of lipids in patients suffering from atherosclerosis, diabetes, fatty liver and so on through the inhibition of lipid peroxide, resulting in the decrease of the elevated serum lipid[1]. Feeding of Riboflavin Tetrabutyrate results in an increase in the hepatic activity of 3-ketoacyl-CoA thiolase by 50% of the control level, while the activities of renal 3-ketoacyl-CoA thiolase and of hepatic and renal acyl-CoA synthetase and acyl-CoA dehydrogenase remain unaffected. The increase in hepatic 3-ketoacyl-CoA thiolase activity suggests that prolonged Riboflavin Tetrabutyrate administration results in an increased beta-oxidation of fatty acid in the liver [2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

656.72

Formula

C33H44N4O10
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(CCC)O[C@H]([C@H](OC(CCC)=O)[C@H](OC(CCC)=O)COC(CCC)=O)CN1C(C=C(C)C(C)=C2)=C2N=C(C(N3)=O)C1=NC3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (152.27 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5227 mL 7.6136 mL 15.2272 mL
5 mM 0.3045 mL 1.5227 mL 3.0454 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References
Animal Administration
[3]

Rats: Riboflavin tetrabutyrate-14C (700 μg, corresponding to 400 μg of riboflavin; total radioactivity 2.19×105 cpm) is suspended in 0.2mL of soybean oil and given per os . In the case of injection, same amount of Riboflavin tetrabutyrate-14C is dissolved in 1mL of soybean oil and injected subcutaneously into the back of rat[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5227 mL 7.6136 mL 15.2272 mL 38.0680 mL
5 mM 0.3045 mL 1.5227 mL 3.0454 mL 7.6136 mL
10 mM 0.1523 mL 0.7614 mL 1.5227 mL 3.8068 mL
15 mM 0.1015 mL 0.5076 mL 1.0151 mL 2.5379 mL
20 mM 0.0761 mL 0.3807 mL 0.7614 mL 1.9034 mL
25 mM 0.0609 mL 0.3045 mL 0.6091 mL 1.5227 mL
30 mM 0.0508 mL 0.2538 mL 0.5076 mL 1.2689 mL
40 mM 0.0381 mL 0.1903 mL 0.3807 mL 0.9517 mL
50 mM 0.0305 mL 0.1523 mL 0.3045 mL 0.7614 mL
60 mM 0.0254 mL 0.1269 mL 0.2538 mL 0.6345 mL
80 mM 0.0190 mL 0.0952 mL 0.1903 mL 0.4758 mL
100 mM 0.0152 mL 0.0761 mL 0.1523 mL 0.3807 mL
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Riboflavin Tetrabutyrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Riboflavin Tetrabutyrate752-56-7Reactive Oxygen SpeciesInhibitorinhibitorinhibit

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