Bacterial Inhibitor

IspE kinase-IN-1 (compound 4) is a potent IspE kinase inhibitor with IC₅₀ values of 6.2, 5.2 µM for EclspE, KplspE, respectively.

SEW-05929 is an inhibitor of E. coli SecA ATPase (N68SecA). SEW-05929 is applicable to research related to SecA ATPase in bacterial protein translocation and bacterial infections.

2-Hydroxycinnamic acid-d₄ is deuterium labeled 2-Hydroxycinnamic acid. 2-Hydroxycinnamic acid is a phenolic acid with antimicrobial and antioxidant properties. 2-Hydroxycinnamic acid has antimicrobial activity against Staphylococcus aureus and is not susceptible to drug resistance. 2-Hydroxycinnamic acid shows inhibitory effects on infection of HIV/SARS-CoV S pseudovirus with an IC₅₀ of 0.3 mM. In addition, 2-Hydroxycinnamic acid has neuroprotective and antitumor activity.

ML344 is an agonist of Vibrio cholerae CqsS, a transmembrane receptor.

ROS inducer 8 (Compound 11g) is the inhibitor for glutathione (GSH), that induces the ROS accumulation in Enterococcus faecalis, thereby exhibiting antibacterial activity. ROS inducer 8 disrupts the biofilm, inhibits S. aureus and E. faecalis with MIC of 8 μg/mL and 2 μg/mL, exhibits post-antibiotic effect. ROS inducer 8 exhibits low hemolytic toxicity to sheep erythrocytes (HC₅₀ > 1280 μg/mL).

Aranochlor A is an antibiotic found in Pseudoarachniotus roseus (HIL Y-30499). Aranochlor A exhibits antibacterial and antifungal activities.

Antibacterial agent 230 (compound 10) is an effective Antifungal agent. The MIC value of antibacterial agent 230 against fluconazole-resistant fungi is 2.0 ~ 16.0 μg/mL.

Hydroquinine (Standard) is the analytical standard of Hydroquinine. Hydroquinine (Dihydroquinine) is an anti-bacterial agent that inhibits both Gram-positive and Gram-negative bacteria. Hydroquinine inhibits the growth of multidrug-resistant pseudomonas aeruginosa via the suppression of the arginine deiminase pathway genes. Hydroquinine inhibits Plasmodium falciparum and Plasmodium berghei. Hydroquinine displays anti-malarial and demelanizing activities. Hydroquinine effectively induces specific RND-type efflux pump systems in Pseudomonas aeruginosa, particularly the MexCD-OprJ and MexXY efflux pumps. Hydroquinine inhibits Pseudomonas aeruginosa adhesion and biofilm formation. Hydroquinine serves as a precursor for derivatives such as C9 epihydroquinine, 9-acetoxy-10,11-dihydroquinine, and 10,11-dihydroquinine monohydrochloride.

Olivomycin B has strong activity against Gram-positive bacteria and weak activity against Gram-negative bacteria.

Tembetarine chloride is a alkaloid that can be isolated from Tinospora cordifolia that exhibits antibacterial activity. Tembetarine chloride exhibits weak cytotoxicity against mouse fibroblasts (L929) and human embryonic kidney cells (HEK293) with IC₅₀ of 1245.33 μg/mL and 1642.81 μg/mL, respectively.

Arginomycin is a nucleoside antibiotic that inhibits the growth of Gram-positive bacteria and fungi in vitro.

Pneumocandin A4 is a lipopeptide antibiotic. Pneumocandin A4 has a strong anti-Candida effect. Pneumocandin A4 has the effect of inhibiting the synthesis of 1,3 early-glucan in vitro, with an IC₅₀ of 0.07-0.5 μg/mL.

Arisostatin B is a Tetrocarcin class of antibiotic against Gram-positive bacteria and antitumor activity.

α-Thujaplicin, the isomer of Hinokitiol (HY-B2230), is an antimicrobial agent. α-Thujaplicin can be isolated from Aomori Hiba (Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO). α-Thujaplicin shows inhibition of Carboxypeptidase A (IC₅₀: 32.4 μM). α-Thujaplicin shows rather strong antifungal activity against seven kinds of plant-pathogenic fungi, their MICs being in the range of 12.0-50.0 μg/mL. α-Thujaplicin shows clear antibacterial activity against Legionella pneumophila SG 1 and L. pneumophila SG 3, and their MICs are in the range of 12.5-50 μg/mL. α-Thujaplicin shows antibacterial activity against Enterococcus faecalis IFO-12965 with a MIC of 1.56 μg/mL. α-Thujaplicin shows germination inhibition toward the seed of Echinochloa utilis Ohwi et Yabuno. α-thujaplicin inhibits lymphocytic leukemia, stomach cancer, Ehrlich’s ascites carcinoma.

Ginkgolic Acid (C13:0) (Standard) is the analytical standard of Ginkgolic Acid (C13:0) (HY-N0078). This product is intended for research and analytical applications. Ginkgolic Acid (C13:0) (Ginkgoneolic Acid) is an anti-cariogenic agent and a PI3Kδ inhibitor (IC₅₀: 2.49 μM). Ginkgolic Acid (C13:0) exhibits antibacterial and anti-parasitic activities. Ginkgolic Acid (C13:0) can also inhibit mast cell degranulation (IC₅₀: 2.40 μM).

Grahamimycin B has weak activity against Gram-positive bacteria, negative bacteria, cyanobacteria and green algae.

Pyrrolomycin B is a pyrrole antibiotic. Pyrrolomycin B has anti-Gram-positive bacteria, anti-Gram-negative bacteria and anti-individual fungi activity.

LB 11058 is a Cephalosporin Antibacterial agent. LB 11058 inhibits the growth of pathogenic bacteria, including multidrug-resistant staphylococci and streptococci, but shows weak activity against Enterococcus faecium, Corynebacterium species, Enterobacteriaceae and non-fermenting Gram-negative bacilli. LB 11058 can be used in bacterial infection research.

Doxycycline fosfatex is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline fosfatex is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and fosfatex atoms. Doxycycline fosfatex also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline fosfatex induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline fosfatex also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline fosfatex has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers.

Chicamycin B has anti-tumor activity and weak anti-Gram-positive bacteria activity.