CCR Inhibitor

Anti-Mouse CCR8 Antibody (C8Mab-2) is an antibody targeting mouse CCR8. Anti-Mouse CCR8 Antibody (C8Mab-2) induces antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis to eliminate CCR8-expressing cells. Anti-Mouse CCR8 Antibody (C8Mab-2) eliminates regulatory T cells in the tumor microenvironment, increases CD8⁺ T cell infiltration and inhibits tumor growth. Anti-Mouse CCR8 Antibody (C8Mab-2) recognizes the N-terminal amino acid region 1-33 of mouse CCR8, in which Thr20 serves as the core binding epitope amino acid. Anti-Mouse CCR8 Antibody (C8Mab-2) is applicable to research related to colon cancer, breast cancer and bladder cancer.

mNOX-E36 is a murine-specific analogue of NOX-E36 (HY-148100), an anti-CCL-2 L-RNA aptamer that binds and neutralises the mouse chemokine CCL-2. mNOX-E36 reduces scarring in an experimental murine model of glaucoma filtration surgery (GFS). mNOX-E36 ameliorates lupus nephritis in mice. mNOX-E36 can be used for GFS and lupus nephritis research.

ZL-1218 is a selective humanized IgG1 antibody, targeting CCR8. ZL-1218 induces antibody-dependent cellular cytotoxicity (ADCC), leading to NK cell-mediated depletion of CCR8-expressing regulatory T cells (Tregs). ZL-1218 blocks the binding of the CCR8 ligand CCL1 to CCR8 and reduces Treg recruitment by inhibiting the chemotaxis of CCR8⁺ cells. ZL-1218 reduces intratumoral Treg levels in a dose-dependent manner. ZL-1218 exerts enhanced antitumor activity when combined with the anti-PD-1 antibody. ZL-1218 can be used for solid tumour research.

R707 is a human antibody expressed in CHO cells that targets CCR7/CD197. R707 contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145.36 kDa. The isotype control for R707 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

C-021 (Standard) is the analytical standard of C-021. This product is intended for research and analytical applications. C-021 is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM.

Ilacirnon (Standard) is the analytical standard of Ilacirnon. This product is intended for research and analytical applications. CCX140 (CCX140-B) is a potent CCR2 antagonist.