2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0850R
    Difenoconazole (Standard)
    		Inhibitor
    Difenoconazole (Standard) is the analytical standard of Difenoconazole. This product is intended for research and analytical applications. Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth.
    Difenoconazole (Standard)
  • HY-117245
    Pallidol
    		Inhibitor
    Pallidol is a potent and selective singlet oxygen quencher. Pallidol shows antioxidant and antifungal activities.
    Pallidol
  • HY-Y0569B
    D-Gluconic acid calcium hydrate
    		Inhibitor 99.88%
    D-Gluconic acid calcium hydrate is the carboxylic acid by the oxidation with antiseptic and chelating properties.
    D-Gluconic acid calcium hydrate
  • HY-117089
    Tetraconazole
    		Inhibitor
    Tetraconazole is a selective irreversible inhibitor of 14-α-sterol demethylase (CYP51) with antifungal activity. Tetraconazole competitively binds to the enzyme to block fungal ergosterol synthesis, resulting in cell membrane damage. The EC50 of tetraconazole against wheat pathogens is 0.382-0.802 mg/L, and the EC50 against onion root tip meristem cell growth is 6.7 mg/L, and (R)-(+)-Tetraconazole is 1.49-1.98 times more active than (S)-(-)-Tetraconazole. Tetraconazole can also induce oxidative stress and chromosomal aberrations in plant cells.
    Tetraconazole
  • HY-N2896
    Arjunolic acid
    		Inhibitor 98.83%
    Arjunolic acid is an orally active, multifunctional bioactive compound. Arjunolic acid exhibits free radical scavenging activity, as well as fungal and bacterial activities. Arjunolic acid induces apoptosis (Apoptosis) in various cancer cells. Arjunolic acid protects hepatocytes against induced oxidative stress and apoptosis by reducing reactive oxygen species and inhibiting NF-κB activation. Arjunolic acid regulates pancreatic dysfunction in type 2 diabetic rats by blocking the activation of the TLR-4/MyD88 and canonical Wnt pathways. Arjunolic acid inhibits neuroinflammation and ameliorates depressive behaviors via the SIRT1/AMPK/Notch1 signaling pathway in microglia. Arjunolic acid improves Crohn's disease-like colitis by restoring gut microbiota composition and inhibiting TLR4 signaling. Arjunolic acid suppresses osteosarcoma progression by inhibiting Wnt3a-mediated M2 polarization of macrophages. Arjunolic acid ameliorates diabetic retinopathy via the autophagy pathway regulated by AMPK/mTOR/HO-1. Arjunolic acid is applicable to research related to type 2 diabetes, organ toxicity, depression, Crohn's disease, osteosarcoma, diabetic retinopathy, and testicular dysfunction.
    Arjunolic acid
  • HY-P2523
    Temporin L
    		Inhibitor 99.85%
    Temporin L is a potent antimicrobial peptide and is active against Gram-negative bacteria and yeast strains. Temporin L also has antiendotoxin properties.
    Temporin L
  • HY-N0452R
    Hyperoside (Standard)
    		Inhibitor
    Hyperoside (Standard) is the analytical standard of Hyperoside. This product is intended for research and analytical applications. Hyperoside is a NF-κB inhibitor, found from Hypericum monogynum. Hyperoside shows anti-tumor, antifungal, anti-inflammatory, anti-viral, and anti-oxidative activities, and can induce apoptosis.
    Hyperoside (Standard)
  • HY-W007355S1
    Skatole-d8
    		Inhibitor 98.50%
    Skatole-d8 is the deuterium labeled Skatole. Skatole is produced by intestinal bacteria, regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.
    Skatole-d<sub>8</sub>
  • HY-N0672
    Pseudolaric Acid C
    		Inhibitor 99.74%
    Pseudolaric C is a diterpenoid isolated from the root bark of Pseudolarix amabilis, has antifungal activity.
    Pseudolaric Acid C
  • HY-N0328R
    alpha-Mangostin (Standard)
    		Inhibitor
    alpha-Mangostin (Standard) is the analytical standard of alpha-Mangostin. This product is intended for research and analytical applications. alpha-Mangostin (α-Mangostin) is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.
    alpha-Mangostin (Standard)
  • HY-B2144G
    Chitosan (≥80% deacetylated, High viscosity,>400mPa.s)
    		Inhibitor
    Chitosan (Deacetylated chitin; Poly(D-glucosamine)) (≥80% deacetylated, High viscosity,>400mPa.s) is a polysaccharide obtained by deacetylating chitin, and exhibits antimicrobial activity against various bacteria and fungi.
    Chitosan (≥80% deacetylated, High viscosity,>400mPa.s)
  • HY-W015664
    2-Methylheptanoic acid
    		Inhibitor 99.31%
    2-Methylheptanoic acid is a flavouring ingredient, isolated from honey.
    2-Methylheptanoic acid
  • HY-N6625R
    Chlorothalonil (Standard)
    		Inhibitor
    Chlorothalonil (Standard) is the analytical standard of Chlorothalonil. This product is intended for research and analytical applications. Chlorothalonil is a broad-spectrum foliar fungicide with oral activity. Chlorothalonil can be used to combat fungal diseases in vegetable and crop leaves. Chlorothalonil can alter the microbial community in the soil. Chlorothalonil inhibits spermatogenesis. Chlorothalonil can cause intestinal epithelial barrier dysfunction and fetal toxicity.
    Chlorothalonil (Standard)
  • HY-40354AS
    Tofacitinib-d3 citrate
    		Inhibitor 99.59%
    Tofacitinib-d3 (citrate) is deuterium labeled Tofacitinib (citrate). Tofacitinib citrate is an orally available JAK1/2/3 inhibitor with IC50s of 1, 20, and 112 nM, respectively. Tofacitinib citrate has antibacterial, antifungal and antiviral activities.
    Tofacitinib-d<sub>3</sub> citrate
  • HY-125699
    Ochratoxin C
    		Inhibitor 99.45%
    Ochratoxin C is the ethyl ester analog of ochratoxin A, a mycotoxin produced by A. ochraceus, A. carbonarius, and P. verrucosum that is commonly found as a food contaminant.
    Ochratoxin C
  • HY-P1791
    Lactoferrin (17-41)
    		Inhibitor 98.98%
    Lactoferrin 17-41 (Lactoferricin B), a peptide corresponding to residues 17-41 of bovine lactoferrin, has antimicrobial activity against a wide range of microorganisms, including Gram-positive and Gramnegative bacteria, viruses, protozoa, and fungi. Lactoferrin 17-41 has antitumor activities.
    Lactoferrin (17-41)
  • HY-N4164
    Schinifoline
    		Inhibitor 99.85%
    Schinifoline is a 4-quinolinone found in Zanthoxylum schinifolium. Schinifoline can inhibit cancer cells proliferation, cause G2/M phase arrest and induce apoptosis. Schinifoline can improve radiosensitizing effect of cancer cells. Schinifoline shows anti-fungal activity. Schinifoline can be used for the researches of cancer and infection, such as lung cancer and C. albicans infection.
    Schinifoline
  • HY-129315
    Deacylketoconazole
    		Inhibitor 99.60%
    Deacylketoconazole (N-Deacetylketoconazole; R-39519) is an orally active metabolite of Ketoconazole (HY-B0105). Deacylketoconazole exhibits antifungal and antibacterial activity. Deacylketoconazole is cytotoxic in rats hepatocyte.
    Deacylketoconazole
  • HY-W1127089
    Antifungal agent 136
    		Inhibitor 99.15%
    Antifungal agent 136 is a CYP51 inhibitor and antifungal agent. Antifungal agent 136 downregulates the expression of interleukin-6 to alleviate inflammatory responses. Antifungal agent 136 exhibits activity against both drug-sensitive and drug-resistant Candida albicans strains. Antifungal agent 136 can be used in the research of fungal infections and inflammatory diseases.
    Antifungal agent 136
  • HY-150686
    Chitin synthase inhibitor 4
    		Inhibitor 98.97%
    Chitin synthase inhibitor 4 (compound 4fh) is a chitin synthase inhibitor with fungicidal effect. Chitin synthase inhibitor 4 is a potential chitin synthase-based fungicide in agriculture.
    Chitin synthase inhibitor 4
Cat. No. Product Name / Synonyms Application Reactivity