14320-81-1
14320-81-1
Chemical Structure
Verazine
Synonym(s): (-)-Verazine
- CAS No.: 14320-81-1
- Formula:C27H43NO
- Molecular Weight:397.64
InChIKey: VRBNGKPRTHBEIQ-LURFOZDGSA-N
SMILES: C[C@]12[C@](CC[C@]1([H])[C@@H](C(CC3)=NC[C@H]3C)C)([H])[C@@](CC=C4C[C@H]5O)([H])[C@@](CC2)([H])[C@]4(CC5)C
Biological Activity: Verazine ((-)-Verazine) is an anti-Fungal Agent that can be found in the dried roots and rhizoma of Veratrum maackii Regel. Verazine causes DNA damage in the cerebellum and cerebral cortex of mice in a dose-dependent manner. Verazine can be used in the study of fungal infections and neurological diseases[1][2].
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Verazine | 99.74% | Verazine ((-)-Verazine) is an anti-Fungal Agent that can be found in the dried roots and rhizoma of Veratrum maackii Regel. Verazine causes DNA damage in the cerebellum and cerebral cortex of mice in a dose-dependent manner. Verazine can be used in the study of fungal infections and neurological diseases. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.74
HY-N15736Petiline -
Similarity Score 0.72
HY-15786SGE-201 -
Similarity Score 0.72
HY-U00424Chol-5-en-24-al-3β-ol -
Similarity Score 0.72
HY-W040150(24S,25)-Epoxycholesterol -
Similarity Score 0.72
HY-W41482324,25-Epoxycholesterol -
Similarity Score 0.72
HY-1694024(S)-Hydroxycholesterol -
Similarity Score 0.72
HY-16940A24(R)-Hydroxycholesterol -
Similarity Score 0.72
HY-N237024-Hydroxycholesterol -
Similarity Score 0.72
HY-11313425-Hydroxycholesterol -
Explore the MedChemAI to find more analogs
References
- [1]. Cong Y, et al. Steroidal Alkaloids from Veratrum maackii Regel with Genotoxicity on Brain-Cell DNA in Mice. Helv Chim Acta. 2015, 98(4): 539-545.
- [2]. Augustin MM, et al. Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells. Plant J. 2015 Jun;82(6):991-1003. [Content Brief]
