Opioid Receptor
Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.
Opioid Receptor Isoform Specific Products
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Opioid Receptor Inhibitors
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Opioid Receptor Agonists
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Opioid Receptor Antagonists
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Opioid Receptor Activators
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Opioid Receptor Modulators
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Opioid Receptor Controls
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Opioid Receptor Ligands
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Opioid Receptor Related Products (614)
Related Products (614)
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Antibodies (3)
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Opioid Receptor Isoform Comparison
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Mu opioid receptor antagonist 8
0 ImagesCat. No.: HY-162669CAS No.: 3040171-60-3Mu opioid receptor antagonist 8 (368) is a μ-opioid receptor antagonist. Mu opioid receptor antagonist 8 (368) significantly inhibits met-enkephalin-induced µOR activation of Gi.
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Riminkefon
0 ImagesCat. No.: HY-P3376CAS No.: 2168572-99-2Riminkefon is a kappa opioid receptor agonist.
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LPK-26 hydrochloride
0 ImagesCat. No.: HY-136654CAS No.: 492451-07-7LPK-26 hydrochloride is a selective kappa-opioid receptor agonist with a Ki of 0.68 nM. LPK-26 exhibits potent antinociceptive effects with low physical dependence potential and can be utilized in relevant research.
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Bilaid A1e
0 ImagesCat. No.: HY-P3044CAS No.: 2393866-02-7Bilaid A1e (Compound 1e) is a tetrapeptide agonist of the µ-opioid receptor (Ki = 750 nM). Bilaid A1e can be isolated from an Australian estuarine isolate of Penicillium sp. Bilaid A1e can be used for pain research.
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Urotensin-II receptor antagonist-1
0 ImagesCat. No.: HY-10672CAS No.: 1034708-07-0Urotensin-II receptor antagonist-1 (compound 1) is a low oral bioavailability (F=0-3%, rat) selective human Urotensin II receptor antagonist, Ki=16 nM (test on HEK293 cells expressing recombinant human UT receptor). Urotensin-II receptor antagonist-1 inhibits cytochrome P450 (IC50=0.75 μM, CYP2D6; 1.4 μM, CYP3A4), inhibits κ-opioid receptor (EC50=3.2 μM), targets cardiac sodium channels (Ki=2.5 μM).
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Faxeladol
0 ImagesCat. No.: HY-14742CAS No.: 433265-65-7Faxeladol is a compound with analgesic activity that reduced mean pain intensity compared with placebo in a suppression trial for painful polyneuropathy with a favorable safety profile.
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LY2048978
0 ImagesCat. No.: HY-118615CAS No.: 676495-11-7LY2048978 is a non-selective opioid receptor antagonist with Ki of 0.287, 0.471 and 1.05 nM for human mu, kappa and delta opioid receptors in vitro, respectively. LY2048978 can be used in the research of major depressive disorder and alcohol use disorder.
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[D-Ala2]-Met-Enkephalinamide
![[D-Ala2]-Met-Enkephalinamide](https://file.medchemexpress.com/product_pic/hy-p3548.gif "Click to View [D-Ala2]-Met-Enkephalinamide Product Detail")
0 ImagesCat. No.: HY-P3548CAS No.: 61090-95-7[D-Ala2]-Met-Enkephalinamide, an opioid peptide, is a potent opioid agonist. [D-Ala2]-Met-Enkephalinamide decreases bile flow by a central mechanism. [D-Ala2]-Met-Enkephalinamide has analgesic properties.
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Mu opioid receptor antagonist 5
0 ImagesCat. No.: HY-144610CAS No.: 1124167-61-8Mu opioid receptor antagonist 5 (compound NAP) is a selective and blood-brain barrier (BBB) penetrant μ opioid receptor (MOR) antagonist with an EC50 value of 1.14 nM and a Ki value of 0.37 nM. Mu opioid receptor antagonist 5 can be used for researching opioid use disorders (OUD).
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Biphalin TFA
0 ImagesCat. No.: HY-P3223CAS No.: 126872-95-5Biphalin TFA, a BBB-penetrable opioid peptide analog, contains two active enkephalin pharmacophores. Biphalin TFA has high affinity for opioid receptors. Biphalin TFA shows analgesic effect in acute, neuropathic, and chronic animal pain models. Biphalin TFA is also an antiviral, antiproliferative, anti-inflammatory, and neuroprotective agent.
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ORL1 antagonist 2
0 ImagesCat. No.: HY-158236CAS No.: 1169982-72-2ORL1 antagonist 2 (1B) is an opioid receptor-Like 1 (ORL1) antagonist, usd in P-glycoprotein (P-gp) research.
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Perillyl acetate
0 ImagesPerillyl acetate is a monoterpene found in in essential oils of plants and is synthesized from perillyl alcohol (HY-N7000). Perillyl acetate can activate the μ-opioid receptor and exert potent analgesic activity. Perillyl acetate can be used for the research of inflammation and neurological disease such as arthritis.
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μ opioid receptor agonist 1
0 ImagesCat. No.: HY-142918CAS No.: 2667632-83-7μ opioid receptor agonist 1 （Compound H-1a）is an optically pure oxaspiro ring substituted pyrrolopyrazole derivative, acts as a MOR receptor agonist and can be used for the research of pain and pain related diseases.
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BAM-22P
0 ImagesSynonyms: Bovine adrenal medulla-22PBAM-22P, a highly potent opioid peptide, is a potent opioid agonist.
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D-Ala-Gly-Phe-Met-NH2
0 ImagesCat. No.: HY-P3555CAS No.: 82948-89-8D-Ala-Gly-Phe-Met-NH2, an opioid peptide, is a potent opiate δ-receptor agonist.
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(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8)
0 ImagesCat. No.: HY-P4679CAS No.: 103613-84-9Synonyms: E2078(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) (E-2078), a stable Dynorphin A (1–8) (HY-P2159) analog, is a kappa opioid receptor (KOR) agonist.
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DDD-028
0 ImagesCat. No.: HY-117091CAS No.: 1538586-09-2DDD-028 is a potent non-opioid, non-cannabinoid analgesic which attenuates neuropathic and inflammatory pain without the possible side effects or abuse potential associated with opioid or cannabinoid activities. DDD-028 can be utilized in analgesic research.
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Tyr-Gly-{Gly-13C2,15N}-Phe-Met-OH TFA
0 ImagesCat. No.: HY-P0073S2Synonyms: Met-Enkephalin-13C2,15N TFA-1; Methionine enkephalin-13C2,15N TFA-1; Metenkefalin-13C2,15N TFA-1Tyr-Gly-{Gly-13C2,15N}-Phe-Met-OH TFA (Met-Enkephalin-13C2,15N TFA-1) is the 13C- and 15N-labeled Tyr-Gly-Gly-Phe-Met-OH TFA. Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.
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Niravoline
0 ImagesCat. No.: HY-133173CAS No.: 130610-93-4Synonyms: RU51599Niravoline (RU51599) is an arginine vasopressin (AVP) release inhibitor and a selective kappa opioid receptor agonist. Niravoline has a pure water diuresis effect without associated electrolyte excretion. Niravoline can reduce brain oedema following transient forebrain ischaemia in rats.
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SRI-22136
0 ImagesCat. No.: HY-175661SRI-22136 is a Delta Opioid Receptor (DOR) antagonist that can cross blood-brain barrier with a IC50 of 0.42 nM. SRI-22136 does not have agonistic activity but antagonistic activity against DOR, MOR (IC50 = 370 nM), KOR (IC50 = 54 nM) and can avoid addiction/aversion effects. SRI-22136 can effectively inhibit the BACE1 activity induced by DADLE (a DOR agonist) (HY-105343) (IC50 = 120 nM). SRI-22136 prevents completely Alzheimer’s-like pathology in mouse model. SRI-22136 can used for the study of Alzheimer’s disease.
