Opioid Receptor
Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.
Opioid Receptor Isoform Specific Products
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Opioid Receptor Inhibitors
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Opioid Receptor Agonists
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Opioid Receptor Antagonists
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Opioid Receptor Activators
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Opioid Receptor Modulators
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Opioid Receptor Controls
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Opioid Receptor Ligands
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Opioid Receptor Related Products (614)
Related Products (614)
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Antibodies (3)
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Opioid Receptor Isoform Comparison
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Ac-RYYRWK-NH2
0 ImagesCat. No.: HY-P1316CAS No.: 200959-47-3Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors.
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[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2
![[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2](https://file.medchemexpress.com/product_pic/hy-p0192.gif "Click to View [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 Product Detail")
0 ImagesCat. No.: HY-P0192CAS No.: 213130-17-7[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 is a nociceptin receptor (ORL1) agonist. [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 strongly depresses the nociceptive flexor reflex in rats. [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 can be used for analgesia research.
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D3R/MOR antagonist 2
0 ImagesCat. No.: HY-149387CAS No.: 3033883-17-6D3R/MOR antagonist 2 (Compound 121) is a D3R/MOR antagonist (Ki: 361 nM and 85.2 nM respectively). D3R/MOR antagonist 2 has the potential to produce analgesic effects through MOR partial agonism, reduce opioid-misuse liability via D3R antagonism.
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(+)-Eseroline
0 ImagesCat. No.: HY-W387210CAS No.: 29347-15-7(+)-Eseroline is an opioid agonist and adenylate cyclase inhibitor (Ki=6-8 μM). (+)-Eseroline binds specifically to μ-opioid receptors and δ-opioid receptors on rat brain cell membranes (Ka=0.7 μM). (+)-Eseroline exhibits only weak activity in various mouse analgesic models and can be used for studies on pain-related mechanisms.
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AH-8533
0 ImagesCat. No.: HY-131930CAS No.: 759397-79-0AH-8533 is a opioid agent.
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Sameridine
0 ImagesCat. No.: HY-105525CAS No.: 143257-97-0Synonyms: NIH 10908 free baseSameridine (NIH-10908 free base) is a weak partial agonist of the μ-opioid receptor. Sameridine shows local anesthetic and analgesic properties. Sameridine has minimal respiratory depression at low doses, but can suppress ventilatory response at high doses. Sameridine can be used for the study of analgesic effect.
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N,N-Diallyl-Tyr-Aib-Aib-Phe-Leu
0 ImagesCat. No.: HY-P2429CAS No.: 92535-15-4N,N-Diallyl-Tyr-Aib-Aib-Phe-Leu is a compound that can antagonize the δ-opioid receptor and the action of [D-Pen2,D-Pen ] enkephalin in vivo. Its antagonistic effect can be verified by specific behavioral experiments.
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Peptide E
0 ImagesCat. No.: HY-P3874CAS No.: 78355-50-7Peptide E is a potent kappa opiate receptor agonist. Peptide E has opiate receptor binding activity with IC50 value of 0.39 μM. Peptide E can be used for the research of central nervous system.
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KOR agonist 5
0 ImagesCat. No.: HY-172407KOR agonist 5 (Compound 10a) is a KOR/MOR modulator with agonistic activity towards KOR and antagonistic activity towards MOR. KOR agonist 5 can effectively block morphine-induced antinociception and inhibition of intestinal motility. KOR agonist 5 can be used in the research of Substance Use Disorder (SUD).
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[Nphe1]Nociceptin(1-13)NH2 TFA
![[Nphe1]Nociceptin(1-13)NH2 TFA](https://file.medchemexpress.com/product_pic/hy-p1320a.gif "Click to View [Nphe1]Nociceptin(1-13)NH2 TFA Product Detail")
0 ImagesCat. No.: HY-P1320A[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2?binds selectively to recombinant nociceptin receptors (pKi=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent.
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BW373U86
0 ImagesCat. No.: HY-107751CAS No.: 155836-50-3Synonyms: SNC86BW373U86 (SNC86) is a δ-opioid receptor agonist with an IC50 of 1.49 nM. BW373U86 shows antidepressant-like effects.
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Allyphenyline oxalate
0 ImagesCat. No.: HY-138839CAS No.: 1092984-08-1Allyphenyline oxalate (compound 9) can enhance the analgesic effect of Morphine. The pKi values of Allyphenyline for α2A, α2B and α2C are 7.24, 6.47 and 7.07, respectively.
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SR16835
0 ImagesCat. No.: HY-120456CAS No.: 1207195-45-6SR16835 has high affinity for both NOPr and MOPr, with full agonist activity for NOPr and partial agonist activity for MOPr. SR16835 has no analgesic effect.
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MK-1925
0 ImagesCat. No.: HY-122561CAS No.: 932705-04-9MK-1925 is an orally active, CNS-penetrant ORL1 receptor antagonist with an IC50 of 8.2 nM. MK-1925 selectively inhibits the ORL1 receptor and shows no significant activity against other opioid receptors or the hERG potassium channel.
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[Arg14,Lys15]Nociceptin
![[Arg14,Lys15]Nociceptin](https://file.medchemexpress.com/product_pic/hy-p1301.gif "Click to View [Arg14,Lys15]Nociceptin Product Detail")
0 ImagesCat. No.: HY-P1301CAS No.: 236098-40-1[Arg14,Lys15]Nociceptin is a highly potent and selective NOP receptor (ORL1; OP4) agonist, with an EC50 of 1 nM. [Arg14,Lys15]Nociceptin displays high selectivity over opioid receptors, with IC50s of 0.32, 280, >10000 and 1500 nM for NOP, μ, δ and κ receptors, respectively.
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NOP antagonist 1
0 ImagesCat. No.: HY-176505CAS No.: 1283095-64-6NOP antagonist 1 (Compound (-)-31) is a nociceptin opioid peptide (NOP) antagonist with a Kb of 8.65 nM. NOP antagonist 1 can be used for neuropsychiatric disorders research.
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[DPro10] Dynorphin A (1-11), porcine
![[DPro10] Dynorphin A (1-11), porcine](https://file.medchemexpress.com/product_pic/hy-p3647.gif "Click to View [DPro10] Dynorphin A (1-11), porcine Product Detail")
0 ImagesCat. No.: HY-P3647CAS No.: 94596-26-6[DPro10] Dynorphin A (1-11), porcine, a N-Alkylated derivative, is a potent κ-opioid receptor agonist with a Ki value of 0.13 nM. [DPro10] Dynorphin A (1-11), porcine has analgesic property.
