Opioid Receptor
Opioid receptors are a group of G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. Opioid receptors are distributed widely in the brain, and are found in the spinal cord and digestive tract. Opioid receptors are molecules, or sites, within the body that are activated by opioid substances. Opioid receptors inhibit the transmission of impulse in excitatory pathways within the human body system. These pathways include the serotonin, catecholamine, and substance P pathways, which are all implicated in pain perception and feelings of well-being. Opioid receptors are further subclassified into mu, delta, and kappa receptors. All the classes, while exhibiting differing modes of action, share some basic similarities. They all are driven by the potassium pump mechanism, which is found on the plasma membrane of the majority of cells.
Opioid Receptor Isoform Specific Products
All Product Categories
-
Opioid Receptor Inhibitors
(23)
View all products
-
Opioid Receptor Agonists
(300)
View all products
-
Opioid Receptor Antagonists
(129)
View all products
-
Opioid Receptor Activators
(32)
View all products
-
Opioid Receptor Modulators
(28)
View all products
-
Opioid Receptor Controls
(7)
View all products
-
Opioid Receptor Ligands
(9)
View all products
-
Opioid Receptor Related Products (615)
Related Products (615)
-
Antibodies (3)
-
Opioid Receptor Isoform Comparison
-
Dermorphin TFA
0 ImagesCat. No.: HY-P0244ACAS No.: 78331-26-7Dermorphin TFA is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain.
-
AH 8532
0 ImagesCat. No.: HY-W325509CAS No.: 786581-55-3AH 8532, an opioid, possesses anti-nociceptive effect and inhibits writhing induced by phenylquinone, with a ED50 of 16 mg/kg in mice orally.
-
DALDA
0 ImagesCat. No.: HY-P3870CAS No.: 118476-85-0DALDA is a potent and highly selective μ-opioid receptor agonist with a Ki of 1.69 nM. DALDA shows antinociceptive and respiratory effects.
-
μ opioid receptor agonist 2
0 ImagesCat. No.: HY-142919CAS No.: 2671755-38-5μ opioid receptor agonist 2 （Compound H-3）is an optically pure oxaspiro ring substituted pyrrolopyrazole derivative, acts as a MOR receptor agonist and can be used for the research of pain and pain related diseases.
-
AH 7959
0 ImagesCat. No.: HY-129661CAS No.: 763023-14-9AH 7959 is an orally active N-substituted cyclohexyl methyl benzamide compound that has analgesic effects, the oral and subcutaneous ED50 of AH 7959 in mice is greater than 100 mg/kg.
![[(pF)Phe4]Nociceptin(1-13)NH2 TFA](https://file.medchemexpress.com/product_pic/hy-p1300a.gif "Click to View [(pF)Phe4]Nociceptin(1-13)NH2 TFA Product Detail")
-
Acetalin-3
0 ImagesCat. No.: HY-P10177CAS No.: 152274-65-2Acetalin-3 (Ac-RFMWMT-NH2), a hexapeptide, is a μ opioid receptor antagonist with high affinity for μ and κ3 opioid receptor, weak affinity for κ1 receptors and no affinity for κ2 receptors.
-
Corydaline (Standard)
0 ImagesCorydaline (Standard) is the analytical standard of Corydaline. This product is intended for research and analytical applications. Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC50 of 226 μM. Corydaline is a μ-opioid receptor (Ki of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC50 of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities.
-
β-Endorphin (1-27) (human)
0 ImagesCat. No.: HY-P5892CAS No.: 76622-84-9β-Endorphin (1-27) (human) is an opioid antagonist that binds μ-, δ-, and κ-opioid receptors with Kis of 5.31, 6.17, and 39.82 nM, respectively. β-Endorphin (1-27) (human) inhibits β-Endorphin (HY-P1502)-induced and etorphine-induced analgesia.
-
Dynorphin (2-17), amide (porcine)
0 ImagesCat. No.: HY-P3625CAS No.: 161874-98-2
-
Deltorphin
0 ImagesCat. No.: HY-129271CAS No.: 119975-64-3Synonyms: Deltorphin A; DermenkephalinDeltorphin (Deltorphin A; Dermenkephalin) is a biological active peptide. (Deltorphin A peptide was isolated from skin extracts of the South American frog, Phyllomedusa sauvagei. Deltorphin A is a potent and selective agonist for the delta-opioid receptor.)
-
Tyr-{Gly-13C2,15N}-Gly-Phe-Met-OH TFA
0 ImagesCat. No.: HY-P0073S1Synonyms: Met-Enkephalin-13C2,15N TFA; Methionine enkephalin-13C2,15N TFA; Metenkefalin-13C2,15N TFATyr-{Gly-13C2,15N}-Gly-Phe-Met-OH TFA (Met-Enkephalin-13C2,15N TFA) is the 13C- and 15N-labeled Tyr-Gly-Gly-Phe-Met-OH TFA. Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.
-
Helianorphin-19
0 ImagesCat. No.: HY-P5907CAS No.: 2883653-86-7Helianorphin-19 is a potent and selective κ-opioid receptor (KOR) activator with a Ki of 21 nM and an EC50 of 45 nM. Helianorphin-19 exhibits strong KOR-specific peripheral analgesic activity in a mouse model of chronic visceral pain.
-
DS34942424
0 ImagesCat. No.: HY-145369CAS No.: 2967655-39-4DS34942424 is an orally potent analgesic without mu opioid receptor agonist activity.
-
Picenadol
0 ImagesCat. No.: HY-106601CAS No.: 79201-85-7Synonyms: LY-150720Picenadol (LY-150720) is an opioid mixed agonist-antagonist analgesic. Picenadol is an external racemic mixture, where its d-isomer (LY136596) is a potent μ-opioid receptor agonist, and the l-isomer (LY136595) is a weak μ-receptor competitive antagonist, which can inhibit the agonist effect and reduce the risk of dependence. Picenadol has anticholinergic activity.
-
Cyclosomatostatin TFA
0 ImagesCat. No.: HY-P1201ACyclosomatostatin TFA is a non-selective somatostatin receptor antagonist that blocks SSTR1-5-mediated signaling. Cyclosomatostatin TFA decreases the ALDH+ stem cell population and sphere formation without affecting cell viability, and reduces cell proliferation. Cyclosomatostatin TFA activates opioid receptors. Cyclosomatostatin TFA can be used for research on arthritis and colorectal cancer.
-
SR14150
0 ImagesCat. No.: HY-121974CAS No.: 709024-69-1SR14150 is a partial agonist of the NOP receptor with high affinity. The biological activity of SR14150 makes it potentially useful for the development of a new generation of multi-target opioids designed to simultaneously improve analgesia and reduce side effects. The activity of SR14150 and its interaction with other opioid receptors may provide new inhibitory options for the management of chronic pain.
-
Tyr-c[D-Lys-p-F-Phe-Phe-Asp]-D-Pro-NH2
![Tyr-c[D-Lys-p-F-Phe-Phe-Asp]-D-Pro-NH2](https://file.medchemexpress.com/product_pic/hy-p11895.gif "Click to View Tyr-c[D-Lys-p-F-Phe-Phe-Asp]-D-Pro-NH2 Product Detail")
0 ImagesCat. No.: HY-P11895CAS No.: 3081054-21-6Tyr-c [D-Lys-p-F-Phe-Phe-Asp]-D-Pro-NH2 is a multi-opioid receptor (Opioid Receptor) modulator, acting as a MOR/KOR agonist and a DOR antagonist. Tyr-c [D-Lys-p-F-Phe-Phe-Asp]-D-Pro-NH2 activates the G protein-mediated cAMP inhibitory pathway and β-arrestin2 recruitment pathway downstream of MOR, with an EC50 of 159 nM for β-arrestin2 recruitment, an EC50 of 1.1 nM for MOR-mediated calcium mobilization, and an EC50 of 397 nM for KOR. Tyr-c [D-Lys-p-F-Phe-Phe-Asp]-D-Pro-NH2 exhibits potent analgesic activity in vivo. It can be used in studies related to opioid receptor function and analgesia.
-
U-54494A
0 ImagesCat. No.: HY-100963CAS No.: 112465-94-8U-54494A is a benzamide derivative related to κ-opioid receptor agonists, U-54494A has an anticonvulsant activity.
