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Cat. No.: HY-158236

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ORL1 antagonist 2

ORL1 antagonist 2 (1B) is an opioid receptor-Like 1 (ORL1) antagonist, usd in P-glycoprotein (P-gp) research.

For research use only. We do not sell to patients.

CAS No.: 1169982-72-2
Formula: C₂₃H₃₂ClN₅O₃
Molecular Weight:461.98

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

ORL1 antagonist 2 Chemical Structure

CAS No.: 1169982-72-2

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

ORL1 antagonist 2 (1B) is an opioid receptor-Like 1 (ORL1) antagonist, usd in P-glycoprotein (P-gp) research^[1].

All Opioid Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	4900 nM Compound: 7a	Displacement of [35S]MK499 from human ERG expressed in HEK293 cells Displacement of [35S]MK499 from human ERG expressed in HEK293 cells	[PMID: 19394217]

Chemical Information

CAS No. 1169982-72-2
Molecular Weight 461.98
Formula C₂₃H₃₂ClN₅O₃
SMILES

O=C(OC)N[C@H]1CC[C@](C)(C(C2=NC3=CC(N4CCN(CC)CC4)=C(Cl)C=C3N2)=O)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jay Conrad, et al. Model of P-Glycoprotein Ligand Binding and Validation with Efflux Substrate Matched Pairs. J Med Chem. 2024 Apr 11;67(7):5854-5865. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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ORL1 antagonist 2

All Opioid Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ORL1 antagonist 2 Related Classifications

HY-158236 Related Classifications