PPAR
Peroxisome proliferator-activated receptors
PPARs (Peroxisome proliferator-activated receptors) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/δ. PPARs play essential roles in the regulation of cellular differentiation, development, and metabolism (carbohydrate, lipid, protein), and tumorigenesis of higher organisms. All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes. Activation of PPAR-α reduces triglyceride level and is involved in regulation of energy homeostasis. Activation of PPAR-γ enhances glucose metabolism, whereas activation of PPAR-β/δ enhances fatty acids metabolism.
PPAR Isoform Specific Products
All Product Categories
-
PPAR Inhibitors
(105)
View all products
-
PPAR Agonists
(336)
View all products
-
PPAR Antagonists
(30)
View all products
-
PPAR Activators
(168)
View all products
-
PPAR Modulators
(41)
View all products
-
PPAR Inducers
(6)
View all products
-
PPAR Controls
(3)
View all products
-
PPAR Ligands
(4)
View all products
-
Peroxisome Proliferator-activated Receptor Proteins
(11)
View all products
-
PPAR alpha Proteins
(2)
View all products
-
PPAR gamma Proteins
(7)
View all products
-
PPAR-delta Proteins
(2)
View all products
-
PPAR Related Products (737)
Related Products (737)
-
Recombinant Proteins (11)
-
Antibodies (4)
-
PPAR Isoform Comparison
-
Eriocalyxin B
0 ImagesEriocalyxin B is a diterpenoid compound that can be isolated from Chinese herb Isodon eriocalyx. Eriocalyxin B exhibits multiple activities, such as anti-cancer, anti-inflammatory, and inhibition of adipogenesis. Eriocalyxin B is capable of inducing apoptosis and autophagy in tumor cells. Eriocalyxin B can be used in the research of cancers, autoimmune diseases, and other conditions.
-
PPARA Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS10919PPARA Human Pre-designed siRNA Set A contains three designed siRNAs for PPARA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
-
Perfluoroheptanesulfonic acid
0 ImagesSynonyms: 1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid; PFHpSPerfluoroheptanesulfonic acid (1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid; PFHpS) is a per- and polyfluoroalkyl substance (PFAS) that penetrates the skin and induces systemic toxicity and immunotoxicity. Perfluoroheptanesulfonic acid reduces the expression of PPARδ in liver tissue; it induces hepatocyte hypertrophy and necrosis in liver tissue and alters serum biochemical markers associated with liver injury. Perfluoroheptanesulfonic acid upregulates genes related to fatty acid metabolism, cell necrosis and inflammation, reduces the relative weights of the spleen and thymus, suppresses humoral immune responses, and alters the composition of immune cell subsets in the spleen and skin. The plasma concentration of Perfluoroheptanesulfonic acid correlates with food intake. Perfluoroheptanesulfonic acid and perfluorooctanesulfonic acid exhibit synchronous pulse events in influent samples from wastewater treatment plants. Perfluoroheptanesulfonic acid can be used in studies related to liver injury and immune system damage.
-
Vitisin A
0 ImagesCat. No.: HY-142026CAS No.: 142449-89-6Synonyms: (+)-Vitisin AVitisin A ((+)-Vitisin A) is an orally active natural product with multiple pharmacological activities including anti-inflammatory, anti-tumor, anti-oxidant, anti-pathogenic microorganism, hypoglycemic and lipid-regulating, anti-osteoporotic, neuroprotective and cardiovascular protective effects. Vitisin A exhibits inhibitory effects on human AChE and MAO-B with IC50 values of 1.29 µM and 4.94 µM, respectively. Vitisin A inhibits the ERK, MAPK, NF-κB, STAT1, HMGCR and TRAF6 pathways, downregulates the related phosphorylation and protein expression, while activates the Nrf2/HO-1 pathway and upregulates p21 expression. Vitisin A induces tumor cell apoptosis and cell cycle arrest, inhibits adipogenesis and lipid accumulation, while alleviates oxidative stress, suppresses inflammatory responses, blocks hepatic fibrosis, Cuproptosis and cholesterol synthesis, and increases the expression levels of central BDNF and TrkB. Vitisin A can be used in the research of tumors, infectious diseases, metabolic diseases, bone and joint diseases, liver diseases, skin injuries, as well as neurodegenerative and cognitive dysfunction-related diseases.
-
Ppara Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS10920Ppara Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ppara gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
-
PPARγ phosphorylation inhibitor 1
0 ImagesPPARγ phosphorylation inhibitor 1 (Compound 10) is a potent PPARγ binder with the IC50 of 24 nM. PPARγ phosphorylation inhibitor 1 inhibits CDK5-mediated phosphorylation of PPARγ Ser273 with the IC50 of 160 nM. PPARγ phosphorylation inhibitor 1 displays negligible PPARγ agonism in a reporter gene assay. Antidiabetic effects.
-
Saringosterol
0 ImagesSaringosterol is an orally active steroid found in Sargassum muticum. Saringosterol is a LXR agonist. Saringosterol can lower cholesterol levels and inhibit the mRNA and protein expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT enhancer-binding protein α (C/EBPα). Saringosterol has anti-obesity, anti-atherosclerosis, anti-Mycobacterium tuberculosis and anti-depressant activities.
-
Arecaidine hydrobromide
0 ImagesArecaidine hydrobromide is a GABA transport system inhibitor. Arecaidine hydrobromide inhibits the proliferation of oral mucosal fibroblasts, increases the secretion of IL-6, TGF-β and TNF-α in cells, downregulates the expression of PPAR-γ and PCK1 in cells, and upregulates the expression of TGF-β1. Arecaidine hydrobromide inhibits the uptake of γ-aminobutyric acid and β-alanine by the central nervous system of cats. Arecaidine hydrobromide inhibits hPAT1-mediated L-[3H]proline uptake in cells. Arecaidine hydrobromide can be used in research related to neurological diseases.
-
BAY-5094
0 ImagesBAY-5094 is a PPAR gamma (PPARG) inverse agonist. BAY-5094 has oral activity. BAY-5094 can be used in the research of luminal bladder cancer.
-
Fisetin-d5
0 ImagesFisetin-d5 is a deuterated labeled Fisetin. Fisetin is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
-
Pparg Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS10926Pparg Mouse Pre-designed siRNA Set A contains three designed siRNAs for Pparg gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
-
Kudinoside D
0 ImagesKudinoside D is a triterpenoid saponin. Kudinoside D is isolated from the leaves of Ilex kudingcha. Kudinoside D enhances the phosphorylation levels of AMPK and its downstream molecule ACC, and inhibits the expression of PPARγ, C/EBPα, SREBP-1c as well as the target genes of adipogenic transcription factors. Kudinoside D inhibits the activity of ANO1. Kudinoside D possesses hypolipidemic activity. Kudinoside D can be used in obesity-related research.
-
Ppard Mouse Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS10923Ppard Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ppard gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
-
Fucoxanthin (Standard)
0 ImagesFucoxanthin (Standard) is the analytical standard of Fucoxanthin. This product is intended for research and analytical applications. Fucoxanthin (all-trans-Fucoxanthin) is a marine carotenoid and shows anti-obesity, anti-diabetic, anti-oxidant, anti-inflammatory and anticancer activities.
-
Anti-NASH agent 1
0 ImagesAnti-NASH agent 1 (compound 3d)，a derivative of Elafibranor (HY-16737)，is a potent agonist of PPAR-α/δ，targeting to nonalcoholic steatohepatitis (NASH). Anti-NASH agent 1 (3-10 mg/kg; 4 weeks) improves hyperlipidemia，liver fat degeneration and liver inflammation in Methionine-choline deficiency (MCD) induced NASH mice model. Anti-NASH agent 1 shows low liver toxicity and potent liver protection effect.
-
PPARG Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS10925PPARG Human Pre-designed siRNA Set A contains three designed siRNAs for PPARG gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
-
Sinigrin hydrate
0 ImagesSynonyms: Allyl-glucosinolate hydrate; 2-Propenyl-glucosinolate hydrateSinigrin (Allyl-glucosinolate) hydrate is an orally active glucosinolate found in cruciferous plants. Sinigrin hydrate possesses multiple activities such as anti-cancer, antibacterial, antifungal, anti-inflammatory, antioxidant, and inhibition of fat synthesis. Sinigrin hydrate can be used in the research of tumors, inflammatory, and metabolic diseases.
-
Fisetin quarterhydrate
0 ImagesCat. No.: HY-N0182AFisetin quarterhydrate is a natural flavonol found in many fruits and vegetables with various benefits, such as antioxidant, anticancer, neuroprotection effects.
