6901-60-6
Chemical Structure
Saringosterol
- CAS No.: 6901-60-6
- Formula:C29H48O2
- Molecular Weight:428.69
InChIKey: OPGVEUGCNGNPSX-SVSQYMGHSA-N
SMILES: C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(C=C)(O)C(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C
Biological Activity: Saringosterol is an orally active steroid found in Sargassum muticum. Saringosterol is a LXR agonist. Saringosterol can lower cholesterol levels and inhibit the mRNA and protein expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT enhancer-binding protein α (C/EBPα). Saringosterol has anti-obesity, anti-atherosclerosis, anti-Mycobacterium tuberculosis and anti-depressant activities[1][2][3][4].
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Saringosterol | Saringosterol is an orally active steroid found in Sargassum muticum. Saringosterol is a LXR agonist. Saringosterol can lower cholesterol levels and inhibit the mRNA and protein expression of peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT enhancer-binding protein α (C/EBPα). Saringosterol has anti-obesity, anti-atherosclerosis, anti-Mycobacterium tuberculosis and anti-depressant activities. | |||||||||||||||||||||
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- [1]. Lee JA, et al. Anti-Obesity Activity of Saringosterol Isolated from Sargassum muticum (Yendo) Fensholt Extract in 3T3-L1 Cells. Phytother Res. 2017 Nov;31(11):1694-1701. [Content Brief]
- [2]. Yan Y, et al. Saringosterol from Sargassum fusiforme Modulates Cholesterol Metabolism and Alleviates Atherosclerosis in ApoE-Deficient Mice. Mar Drugs. 2021 Aug 26;19(9):485. [Content Brief]
- [3]. Wächter GA, et al. Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens. J Nat Prod. 2001;64(11):1463-1464. [Content Brief]
- [4]. Jin H G, et al. Antidepressant-like effects of saringosterol, a sterol from Sargassum fusiforme by performing in vivo behavioral tests[J]. Medicinal Chemistry Research, 2017, 26(5): 909-915.
Keywords
