Perfluoroheptanesulfonic acid
Based on 1 Customer Validation
Perfluoroheptanesulfonic acid (1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid; PFHpS) is a per- and polyfluoroalkyl substance (PFAS) that penetrates the skin and induces systemic toxicity and immunotoxicity. Perfluoroheptanesulfonic acid reduces the expression of PPARδ in liver tissue; it induces hepatocyte hypertrophy and necrosis in liver tissue and alters serum biochemical markers associated with liver injury. Perfluoroheptanesulfonic acid upregulates genes related to fatty acid metabolism, cell necrosis and inflammation, reduces the relative weights of the spleen and thymus, suppresses humoral immune responses, and alters the composition of immune cell subsets in the spleen and skin. The plasma concentration of Perfluoroheptanesulfonic acid correlates with food intake. Perfluoroheptanesulfonic acid and perfluorooctanesulfonic acid exhibit synchronous pulse events in influent samples from wastewater treatment plants. Perfluoroheptanesulfonic acid can be used in studies related to liver injury and immune system damage.
For research use only. We do not sell to patients.
- Purity : 97.68%
- CAS No.: 375-92-8
- Formula: C7HF15O3S
- Molecular Weight:450.12
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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1,2,3,4,7,8,9-Heptachlorodibenzofuran
Biological Activity
Description
IC50 & Target
[1]|
PPARδ |
In Vitro
Perfluoroheptanesulfonic acid (PFHpS) can reach a peak concentration of 18 ng/L during pulse discharge events in influent water of wastewater treatment plants; to reliably detect its concentration fluctuations, at least 9 random hourly grab samples need to be collected per day[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Perfluoroheptanesulfonic acid (0.625-2.5% w/v; topical; daily; 10 days) suppresses the spleen humoral immune response to sheep red blood cells (with up to 62.3% reduced total IgM activity) and alters splenic immune cell populations in female B6C3F1 mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B6C3F1 (female, 7-8 weeks old)[1]
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Dosage:0.3125% w/v; 0.625% w/v; 1.25% w/v
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Administration:topical; daily; 28 days
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Result:Elevated systemic PFHpS burdens in serum and urine following dermal exposure across gradient dosage groups.
Altered organ relative weights for liver, spleen and thymus in a dose‑dependent manner.
Disrupted serum biochemical profiles involving lipid, glucose and liver‑injury markers.
Produced hepatic histopathological injuries including hepatocellular hypertrophy and focal necrosis.
Triggered skin histological changes such as epidermal hyperplasia and disturbed skin‑barrier‑related gene transcription.
Remodeled transcriptional profiles of hepatic lipid‑metabolism, necrosis‑related genes under high‑dose conditions.
Disturbed immune‑cell subset composition in skin, draining lymph nodes and spleen.
Induced modest transcriptional changes of innate‑immunity‑associated genes within splenic tissue.
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Animal Model:B6C3F1 (female, 7-8 weeks old)[1]
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Dosage:0.625% w/v; 1.25% w/v; 2.5% w/v
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Administration:topical; daily; 10 days
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Result:Suppressed splenic IgM‑mediated humoral immune responses without altering circulating anti‑SRBC IgM levels.
Augmented NK‑cell cytotoxic function at high dosages.
Remodeled multiple splenic immune‑cell populations and up‑regulated surface activation‑associated molecular expression on immune cells.
Chemical Information
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CAS No. 375-92-8
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Appearance Oil
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Molecular Weight 450.12
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Formula C7HF15O3S
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Color Colorless to light yellow
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SMILES
O=S(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)(O)=O
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Synonyms
1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid; PFHpS
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 10 mg/mL (22.22 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (287 KB)
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SDS (701 KB)
- English - EN (701 KB)
- Français - FR (701 KB)
- Deutsch - DE (701 KB)
- Norwegian - NO (701 KB)
- Español - ES (701 KB)
- Swedish - SV (701 KB)
- Italian - IT (701 KB)
- Korean - KR (701 KB)
- Portuguese - PT (701 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2216 mL | 11.1081 mL | 22.2163 mL | 55.5407 mL |
| 5 mM | 0.4443 mL | 2.2216 mL | 4.4433 mL | 11.1081 mL | |
| 10 mM | 0.2222 mL | 1.1108 mL | 2.2216 mL | 5.5541 mL | |
| 15 mM | 0.1481 mL | 0.7405 mL | 1.4811 mL | 3.7027 mL | |
| 20 mM | 0.1111 mL | 0.5554 mL | 1.1108 mL | 2.7770 mL |
Perfluoroheptanesulfonic acid Related Classifications
HY-21200 Related Classifications
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