375-92-8
Chemical Structure
Perfluoroheptanesulfonic acid
Synonym(s): 1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid; PFHpS
- CAS No.: 375-92-8
- Formula:C7HF15O3S
- Molecular Weight:450.12
IUPAC Name: 1,1,2,2,3,3,4,4,5,5,6,6,7,7,7-pentadecafluoroheptane-1-sulfonic acid
InChIKey: OYGQVDSRYXATEL-UHFFFAOYSA-N
SMILES: O=S(C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)(O)=O
Biological Activity: Perfluoroheptanesulfonic acid (1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid; PFHpS) is a per- and polyfluoroalkyl substance (PFAS) that penetrates the skin and induces systemic toxicity and immunotoxicity. Perfluoroheptanesulfonic acid reduces the expression of PPARδ in liver tissue; it induces hepatocyte hypertrophy and necrosis in liver tissue and alters serum biochemical markers associated with liver injury. Perfluoroheptanesulfonic acid upregulates genes related to fatty acid metabolism, cell necrosis and inflammation, reduces the relative weights of the spleen and thymus, suppresses humoral immune responses, and alters the composition of immune cell subsets in the spleen and skin. The plasma concentration of Perfluoroheptanesulfonic acid correlates with food intake. Perfluoroheptanesulfonic acid and perfluorooctanesulfonic acid exhibit synchronous pulse events in influent samples from wastewater treatment plants. Perfluoroheptanesulfonic acid can be used in studies related to liver injury and immune system damage[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Perfluoroheptanesulfonic acid | 97.68% | Perfluoroheptanesulfonic acid (1-Perfluoroheptanesulfonic acid; Perfluoroheptanesulphonic acid; PFHpS) is a per- and polyfluoroalkyl substance (PFAS) that penetrates the skin and induces systemic toxicity and immunotoxicity. Perfluoroheptanesulfonic acid reduces the expression of PPARδ in liver tissue; it induces hepatocyte hypertrophy and necrosis in liver tissue and alters serum biochemical markers associated with liver injury. Perfluoroheptanesulfonic acid upregulates genes related to fatty acid metabolism, cell necrosis and inflammation, reduces the relative weights of the spleen and thymus, suppresses humoral immune responses, and alters the composition of immune cell subsets in the spleen and skin. The plasma concentration of Perfluoroheptanesulfonic acid correlates with food intake. Perfluoroheptanesulfonic acid and perfluorooctanesulfonic acid exhibit synchronous pulse events in influent samples from wastewater treatment plants. Perfluoroheptanesulfonic acid can be used in studies related to liver injury and immune system damage. | ||||||||||||||||||||
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- [1]. Weatherly LM, et al. Systemic and immunotoxicity induced by topical application of perfluoroheptane sulfonic acid (PFHpS) or perfluorooctane sulfonic acid (PFOS) in a murine model. Journal of immunotoxicology. 2024 Dec;21(1):2371868.
- [2]. Szabo D, et al. High-resolution temporal wastewater treatment plant investigation to understand influent mass flux of per- and polyfluoroalkyl substances (PFAS). Journal of hazardous materials. 2023 Apr 05;447:130854.
- [3]. Li S, et al. Examining disparities in PFAS plasma concentrations: Impact of drinking water contamination, food access, proximity to industrial facilities and superfund sites. Environmental research. 2025 Jan 01;264(Pt 1):120370.
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