PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4100)
Related Products (4100)
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PROTAC Linkers Isoform Comparison
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TCO-PEG4-biotin
0 ImagesCat. No.: HY-141183CAS No.: 2183440-30-2
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Fmoc-aminooxy-PFP ester
0 ImagesCat. No.: HY-133404CAS No.: 2752177-95-8
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Benzyl-PEG5-amine
0 ImagesCat. No.: HY-140743CAS No.: 86770-77-6
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TCO-PEG8-TFP ester
0 ImagesCat. No.: HY-141173CAS No.: 2353410-06-5
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m-PEG13-azide
0 ImagesCat. No.: HY-138717Purity: 98.0%m-PEG13-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG13-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Amino-PEG11-amine
0 ImagesCat. No.: HY-130411CAS No.: 479200-82-3
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m-PEG12-Thiol
0 ImagesCat. No.: HY-141331CAS No.: 2413368-61-1
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Ms-PEG4-MS
0 ImagesCat. No.: HY-42774CAS No.: 55400-73-2Synonyms: 1,11-Bis(methanesulfonyloxy)-3,6,9-trioxandecane
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Diketone-PEG4-Biotin
0 ImagesCat. No.: HY-140448CAS No.: 2353409-85-3
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DBCO-NHCO-PEG13-NHS ester
0 ImagesCat. No.: HY-140276CAS No.: 2784618-59-1
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Azido-PEG11-azide
0 ImagesAzido-PEG11-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG11-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride
0 Imagescis-4-Hydroxy-D-proline hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-D-proline hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
