PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4098)
Related Products (4098)
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PROTAC Linkers Isoform Comparison
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HS-PEG3-CH2CH2NH2
0 ImagesCat. No.: HY-130871CAS No.: 1189760-69-7Synonyms: Thiol-PEG3-amine
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Tos-PEG4-t-butyl ester
0 ImagesCat. No.: HY-130422CAS No.: 217817-01-1Synonyms: Tos-PEG4-BocTos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM.
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Propargyl-PEG2-Boc
0 ImagesCat. No.: HY-130597CAS No.: 1807503-80-5
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Propynyl-PEG1-Ac
0 ImagesCat. No.: HY-W096146CAS No.: 944561-45-9
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N-(Acid-PEG2)-N-bis(PEG3-azide)
0 ImagesN-(Acid-PEG2)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Acid-PEG2)-N-bis(PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride
0 ImagesCat. No.: HY-117519ACAS No.: 1416771-72-6Amino-Tri-(carboxyethoxymethyl)-methane hydrochloride is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-Tri-(carboxyethoxymethyl)-methan hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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Azido-PEG8-CH2COO-PFP
0 ImagesAzido-PEG8-CH2COO-PFP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG8-CH2COO-PFP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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PC Azido-PEG11-NHS carbonate ester
0 ImagesCat. No.: HY-140142PC Azido-PEG11-NHS carbonate ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PC Azido-PEG11-NHS carbonate ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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DBCO-PEG5-acid
0 ImagesCat. No.: HY-140267CAS No.: 2764923-65-9
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Boc-C1-PEG3-C4-OH
0 ImagesCat. No.: HY-130618CAS No.: 2376724-97-7Boc-C1-PEG3-C4-OH is a PROTAC linker, which refers to the Alkyl/ether composition. Boc-C1-PEG3-C4-OH can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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Boc-Aminooxy-PEG4-NH2
0 ImagesCat. No.: HY-140438CAS No.: 2062663-66-3
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Hydroxy-PEG6-CH2-Boc
0 ImagesCat. No.: HY-141211CAS No.: 297162-47-1
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Chloro-PEG2-Boc
0 ImagesCat. No.: HY-W096145CAS No.: 1442085-43-9
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Biotin-PEG6-acid
0 ImagesCat. No.: HY-133176CAS No.: 1352814-10-8
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m-PEG10000-OH
0 ImagesSynonyms: mPEG10000-Hydroxy; Polyethylene glycol monomethyl ether 10000m-PEG10000-OH (mPEG10000-Hydroxy; Polyethylene glycol monomethyl ether 10000) is a hydroxyl-terminated methoxylated polyethylene glycol (PEG-based) compound that serves as a linker for PROTACs. m-PEG10000-OH is applicable to research on healthcare-associated infections.
