2. PROTAC
  3. PROTAC Linkers
  4. Boc-C1-PEG3-C4-OH

Boc-C1-PEG3-C4-OH is a PROTAC linker, which refers to the Alkyl/ether composition. Boc-C1-PEG3-C4-OH can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

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Boc-C1-PEG3-C4-OH Chemical Structure

Boc-C1-PEG3-C4-OH Chemical Structure

CAS No. : 2376724-97-7

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25 mg USD 138 In-stock
50 mg USD 220 In-stock
100 mg USD 350 In-stock
250 mg USD 680 In-stock
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Based on 1 publication(s) in Google Scholar

Boc-C1-PEG3-C4-OH Related Antibodies

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Description

Boc-C1-PEG3-C4-OH is a PROTAC linker, which refers to the Alkyl/ether composition. Boc-C1-PEG3-C4-OH can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

IC50 & Target[1]

Alkyl/ether

 

Molecular Weight

320.42

Formula

C16H32O6
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)COCCOCCOCCCCCCO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (156.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1209 mL 15.6045 mL 31.2090 mL
5 mM 0.6242 mL 3.1209 mL 6.2418 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1209 mL 15.6045 mL 31.2090 mL 78.0226 mL
5 mM 0.6242 mL 3.1209 mL 6.2418 mL 15.6045 mL
10 mM 0.3121 mL 1.5605 mL 3.1209 mL 7.8023 mL
15 mM 0.2081 mL 1.0403 mL 2.0806 mL 5.2015 mL
20 mM 0.1560 mL 0.7802 mL 1.5605 mL 3.9011 mL
25 mM 0.1248 mL 0.6242 mL 1.2484 mL 3.1209 mL
30 mM 0.1040 mL 0.5202 mL 1.0403 mL 2.6008 mL
40 mM 0.0780 mL 0.3901 mL 0.7802 mL 1.9506 mL
50 mM 0.0624 mL 0.3121 mL 0.6242 mL 1.5605 mL
60 mM 0.0520 mL 0.2601 mL 0.5202 mL 1.3004 mL
80 mM 0.0390 mL 0.1951 mL 0.3901 mL 0.9753 mL
100 mM 0.0312 mL 0.1560 mL 0.3121 mL 0.7802 mL
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Boc-C1-PEG3-C4-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Boc-C1-PEG3-C4-OH2376724-97-7PROTAC LinkersInhibitorinhibitorinhibit

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