PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4100)
Related Products (4100)
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PROTAC Linkers Isoform Comparison
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Fmoc-PEG3-C2-NHS ester
0 ImagesCat. No.: HY-120773CAS No.: 1352827-47-4
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Sulfo DBCO-PEG4-Maleimide
0 ImagesCat. No.: HY-140307CAS No.: 2055198-07-5
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Cyclohexane-1,4-diamine
0 ImagesCat. No.: HY-W007732BCAS No.: 3114-70-3Synonyms: 1,4-DiaminocyclohexaneCyclohexane-1,4-diamine (1,4-Diaminocyclohexane) is a PROTAC Linker and can be used for PROTAC synthesis, such as TYD-68 (HY-173357).
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tert-Butyl hex-5-ynoate
0 ImagesCat. No.: HY-W411604CAS No.: 73448-14-3tert-Butyl hex-5-ynoate is the linker that can be used for PROTAC synthesis of PROTAC cGAS degrader-1 (HY-172208).
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cis-4-Hydroxy-L-proline hydrochloride
0 ImagesCat. No.: HY-W019213CAS No.: 441067-49-8cis-4-Hydroxy-L-proline hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). cis-4-Hydroxy-L-proline hydrochloride is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid
0 Images2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid is a PROTACT linker and can be used for synthesis of P60-L3-VHL (HY-162943). 2-(2-(2-(6-Azidohexanamido)ethoxy)ethoxy)acetic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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m-PEG2-O-Ph-3-NH2
0 ImagesCat. No.: HY-W096118CAS No.: 126415-02-9
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m-PEG2-O-Ph-NH2
0 ImagesCat. No.: HY-W096113CAS No.: 65673-48-5
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N-(Azido-PEG4)-biocytin
0 ImagesCat. No.: HY-140919CAS No.: 2055042-70-9N-(Azido-PEG4)-biocytin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG4)-biocytin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Methylamino-PEG1-Boc
0 ImagesCat. No.: HY-140154CAS No.: 1807521-03-4Synonyms: Methylamino-PEG1-t-butyl ester
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Fluorescein-PEG6-bis-NHS ester
0 ImagesCat. No.: HY-141084CAS No.: 2055105-59-2
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Azido-PEG2-propargyl
0 ImagesCat. No.: HY-138740CAS No.: 1245006-63-6Azido-PEG2-propargyl is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-propargyl is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-(Azido-PEG3)-N-Boc-PEG4-Boc
0 ImagesCat. No.: HY-140565CAS No.: 2112731-94-7N-(Azido-PEG3)-N-Boc-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG3)-N-Boc-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-(Azido-PEG4)-N-bis(PEG4-acid)
0 ImagesCat. No.: HY-140519CAS No.: 2093152-80-6N-(Azido-PEG4)-N-bis(PEG4-acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG4)-N-bis(PEG4-acid) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
