Methylamino-PEG1-Boc
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Methylamino-PEG1-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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- Reinheit: 95.0%
- CAS. Nr.: 1807521-03-4
- Formel: C10H21NO3
- Molecular Weight:203.28
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Speicherung:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biologische Aktivität
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PEGs |
Alkyl/ether |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1807521-03-4
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Appearance Liquid
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Molecular Weight 203.28
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Formel C10H21NO3
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Color Colorless to light yellow
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SMILES
O=C(OC(C)(C)C)CCOCCNC
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Synonyms
Methylamino-PEG1-t-butyl ester
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Lösungsmittel & Löslichkeit
DMSO : 175 mg/mL (860.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.9193 mL | 24.5966 mL | 49.1932 mL | 122.9831 mL |
| 5 mM | 0.9839 mL | 4.9193 mL | 9.8386 mL | 24.5966 mL | |
| 10 mM | 0.4919 mL | 2.4597 mL | 4.9193 mL | 12.2983 mL | |
| 15 mM | 0.3280 mL | 1.6398 mL | 3.2795 mL | 8.1989 mL | |
| 20 mM | 0.2460 mL | 1.2298 mL | 2.4597 mL | 6.1492 mL | |
| 25 mM | 0.1968 mL | 0.9839 mL | 1.9677 mL | 4.9193 mL | |
| 30 mM | 0.1640 mL | 0.8199 mL | 1.6398 mL | 4.0994 mL | |
| 40 mM | 0.1230 mL | 0.6149 mL | 1.2298 mL | 3.0746 mL | |
| 50 mM | 0.0984 mL | 0.4919 mL | 0.9839 mL | 2.4597 mL | |
| 60 mM | 0.0820 mL | 0.4099 mL | 0.8199 mL | 2.0497 mL | |
| 80 mM | 0.0615 mL | 0.3075 mL | 0.6149 mL | 1.5373 mL | |
| 100 mM | 0.0492 mL | 0.2460 mL | 0.4919 mL | 1.2298 mL |