PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Azido-PEG10-alcohol
0 ImagesCat. No.: HY-140801CAS No.: 877239-09-3Azido-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG10-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Cbz-PEG2-bromide
0 ImagesCat. No.: HY-W190968CAS No.: 2100283-00-7
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Azido-PEG9-alcohol
0 ImagesCat. No.: HY-140800CAS No.: 1984776-37-5Azido-PEG9-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG9-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Benzyl-PEG2-azide
0 ImagesBenzyl-PEG2-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Benzyl-PEG2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Azido-PEG23-C2-azide
0 ImagesCat. No.: HY-138358Azido-PEG23-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG23-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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DBCO-PEG4-triethoxysilane
0 ImagesCat. No.: HY-140308CAS No.: 2353410-02-1
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(+)-Biotin-SLC
0 ImagesCat. No.: HY-130887CAS No.: 1864003-57-5
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Boc-C5-O-C5-O-C6-Cl
0 ImagesCat. No.: HY-108372CAS No.: 1835705-52-6Synonyms: PROTAC Linker 2
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TCO4-PEG3-Maleimide
0 ImagesCat. No.: HY-W872575CAS No.: 1914971-04-2
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Propargyl-PEG8-Boc
0 ImagesCat. No.: HY-130375CAS No.: 2055014-96-3
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Propargyl-PEG12-OH
0 ImagesCat. No.: HY-117045CAS No.: 1036204-61-1
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N-Mal-N-bis(PEG2-NH-Boc)
0 ImagesCat. No.: HY-140574CAS No.: 2128735-26-0
