PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Methylamino-PEG3-azide
0 ImagesCat. No.: HY-140158CAS No.: 1355197-57-7Methylamino-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Methylamino-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-(Boc-PEG1)-N-bis(PEG2-propargyl)
0 ImagesCat. No.: HY-140090CAS No.: 2100306-63-4N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Boc-PEG1)-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Azido-PEG24-acid
0 ImagesAzido-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG24-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Bis-PEG4-PFP ester
0 ImagesCat. No.: HY-126998CAS No.: 1314378-12-5
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Methyltetrazine-amido-PEG5-alkyne
0 ImagesCat. No.: HY-141276CAS No.: 2322322-23-4
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Azido-PEG6-MS
0 ImagesCat. No.: HY-138363CAS No.: 352439-38-4Azido-PEG6-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-MS is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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m-PEG4-NH-DBCO
0 ImagesCat. No.: HY-140315CAS No.: 2228857-36-9
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Amino-PEG13-amine
0 ImagesSynonyms: H2N-PEG13-CH2CH2NH2
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Mal-NH-Boc
0 ImagesCat. No.: HY-140991CAS No.: 134272-63-2
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TCO-PEG4-DBCO
0 ImagesCat. No.: HY-140310CAS No.: 1801863-88-6TCO-PEG4-DBCO is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG4-DBCO is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). TCO-PEG4-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. TCO-PEG4-DBCO also contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
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Propargyl-PEG8-bromide
0 ImagesCat. No.: HY-130377CAS No.: 2055046-25-6Propargyl-PEG8-bromide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-bromide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG8-bromide is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Suberic acid-d12
0 ImagesSynonyms: Octanedioic acid-d12Suberic acid-d12 (Octanedioic acid-d12) is the deuterated-labeled Suberic acid (HY-W015300). Suberic acid (Octanedioic acid) is an orally active crystalline dibasic acid. Suberic acid activates the Akt signaling pathway and regulates the expression of molecules related to the TGF-β and MAPK signaling pathways. Suberic acid inhibits skin dryness.
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N-(Boc-PEG3)-N-bis(PEG3-acid)
0 ImagesCat. No.: HY-140536CAS No.: 2055042-61-8
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m-PEG10-azide
0 Imagesm-PEG10-azide a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG10-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
