PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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N-Mal-N-bis(PEG4-NHS ester)
0 ImagesCat. No.: HY-140572CAS No.: 2112738-60-8
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endo-BCN-PEG3-NH2
0 ImagesCat. No.: HY-133401CAS No.: 1883512-27-3
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Br-PEG4-THP
0 ImagesCat. No.: HY-138372CAS No.: 1803547-60-5
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16-Aminohexadecanoic acid
0 Images16-Aminohexadecanoic acid is an alkane chain with terminal carboxlic acid and amine groups. 16-Aminohexadecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.
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Bromo-PEG7-alcohol
0 ImagesCat. No.: HY-132087CAS No.: 86220-35-1
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BocNH-PEG4-CH2CHO
0 ImagesCat. No.: HY-138408CAS No.: 2708026-80-4
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N-(PEG3-acid)-N-bis(PEG3-amine)
0 ImagesCat. No.: HY-140246CAS No.: 2183440-35-7
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m-PEG10-acid
0 Imagesm-PEG10-acid is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG10-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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Monoethyl pimelate
0 ImagesCat. No.: HY-W016087CAS No.: 33018-91-6
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DBCO-PEG3-amine
0 ImagesCat. No.: HY-134714CAS No.: 2093409-57-3
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DOTA-(t-butyl)3-PEG5-azide
0 ImagesCat. No.: HY-140753Purity: 99.69%DOTA-(t-butyl)3-PEG5-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DOTA-(t-butyl)3-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Mal-PEG6-PFP ester
0 ImagesCat. No.: HY-130454CAS No.: 1599486-33-5
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1,3-bis(carboxyethoxy)-2,2-bis(carboxyethoxy)propane
0 ImagesCat. No.: HY-140527CAS No.: 35638-19-8
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m-PEG2-CH2CH2COOH
0 ImagesCat. No.: HY-W043725CAS No.: 209542-49-4
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Propargyl-PEG2-MS
0 ImagesCat. No.: HY-130584CAS No.: 943726-01-0
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endo-BCN-PEG2-acid
0 ImagesCat. No.: HY-130557CAS No.: 1993134-72-7
