2. PROTAC
  3. PROTAC Linkers
  4. Mal-Amido-PEG4-Boc

Mal-Amido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Mal-Amido-PEG4-Boc Chemical Structure

Mal-Amido-PEG4-Boc Chemical Structure

CAS No. : 1415800-35-9

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100 mg USD 180 In-stock
250 mg USD 350 In-stock
500 mg USD 540 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Mal-Amido-PEG4-Boc Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Mal-Amido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mal-Amido-PEG4-Boc Related Antibodies
Molecular Weight

472.53

Formula

C22H36N2O9
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(OC(C)(C)C)CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (423.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1163 mL 10.5813 mL 21.1627 mL
5 mM 0.4233 mL 2.1163 mL 4.2325 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1163 mL 10.5813 mL 21.1627 mL 52.9067 mL
5 mM 0.4233 mL 2.1163 mL 4.2325 mL 10.5813 mL
10 mM 0.2116 mL 1.0581 mL 2.1163 mL 5.2907 mL
15 mM 0.1411 mL 0.7054 mL 1.4108 mL 3.5271 mL
20 mM 0.1058 mL 0.5291 mL 1.0581 mL 2.6453 mL
25 mM 0.0847 mL 0.4233 mL 0.8465 mL 2.1163 mL
30 mM 0.0705 mL 0.3527 mL 0.7054 mL 1.7636 mL
40 mM 0.0529 mL 0.2645 mL 0.5291 mL 1.3227 mL
50 mM 0.0423 mL 0.2116 mL 0.4233 mL 1.0581 mL
60 mM 0.0353 mL 0.1764 mL 0.3527 mL 0.8818 mL
80 mM 0.0265 mL 0.1323 mL 0.2645 mL 0.6613 mL
100 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.5291 mL
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Mal-Amido-PEG4-Boc Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mal-Amido-PEG4-Boc1415800-35-9PROTAC LinkersInhibitorinhibitorinhibit

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