1. PROTAC
  2. PROTAC Linkers
  3. 16-Aminohexadecanoic acid

16-Aminohexadecanoic acid is an alkane chain with terminal carboxlic acid and amine groups. 16-Aminohexadecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.

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16-Aminohexadecanoic acid

16-Aminohexadecanoic acid Chemical Structure

CAS No. : 17437-22-8

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Description

16-Aminohexadecanoic acid is an alkane chain with terminal carboxlic acid and amine groups. 16-Aminohexadecanoic acid can be used as a PROTAC linker in the synthesis of PROTACs. The amino group (NH2) is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can react with primary amine groups of activated NHS ester to form a stable amide bond.

Molecular Weight

271.44

Formula

C16H33NO2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCCCCCCCCCCCCCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 17.99 mg/mL (66.28 mM; ultrasonic and adjust pH to 2 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6841 mL 18.4203 mL 36.8406 mL
5 mM 0.7368 mL 3.6841 mL 7.3681 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6841 mL 18.4203 mL 36.8406 mL 92.1014 mL
5 mM 0.7368 mL 3.6841 mL 7.3681 mL 18.4203 mL
10 mM 0.3684 mL 1.8420 mL 3.6841 mL 9.2101 mL
15 mM 0.2456 mL 1.2280 mL 2.4560 mL 6.1401 mL
20 mM 0.1842 mL 0.9210 mL 1.8420 mL 4.6051 mL
25 mM 0.1474 mL 0.7368 mL 1.4736 mL 3.6841 mL
30 mM 0.1228 mL 0.6140 mL 1.2280 mL 3.0700 mL
40 mM 0.0921 mL 0.4605 mL 0.9210 mL 2.3025 mL
50 mM 0.0737 mL 0.3684 mL 0.7368 mL 1.8420 mL
60 mM 0.0614 mL 0.3070 mL 0.6140 mL 1.5350 mL
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16-Aminohexadecanoic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
16-Aminohexadecanoic acid
Cat. No.:
HY-23629
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