Azido-PEG24-acid
Based on 1 Customer Validation
Azido-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG24-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 2195075-62-6
- Formula: C51H101N3O26
- Molecular Weight:1172.35
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2195075-62-6
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Appearance Solid
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Molecular Weight 1172.35
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Formula C51H101N3O26
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Color White to light yellow
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SMILES
OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (85.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8530 mL | 4.2649 mL | 8.5299 mL | 21.3247 mL |
| 5 mM | 0.1706 mL | 0.8530 mL | 1.7060 mL | 4.2649 mL | |
| 10 mM | 0.0853 mL | 0.4265 mL | 0.8530 mL | 2.1325 mL | |
| 15 mM | 0.0569 mL | 0.2843 mL | 0.5687 mL | 1.4216 mL | |
| 20 mM | 0.0426 mL | 0.2132 mL | 0.4265 mL | 1.0662 mL | |
| 25 mM | 0.0341 mL | 0.1706 mL | 0.3412 mL | 0.8530 mL | |
| 30 mM | 0.0284 mL | 0.1422 mL | 0.2843 mL | 0.7108 mL | |
| 40 mM | 0.0213 mL | 0.1066 mL | 0.2132 mL | 0.5331 mL | |
| 50 mM | 0.0171 mL | 0.0853 mL | 0.1706 mL | 0.4265 mL | |
| 60 mM | 0.0142 mL | 0.0711 mL | 0.1422 mL | 0.3554 mL | |
| 80 mM | 0.0107 mL | 0.0533 mL | 0.1066 mL | 0.2666 mL |
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