2. PROTAC
  3. PROTAC Linkers
  4. Azido-PEG24-acid

Azido-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG24-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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Azido-PEG24-acid Chemical Structure

Azido-PEG24-acid Chemical Structure

CAS No. : 2195075-62-6

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5 mg USD 32 In-stock
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25 mg USD 80 In-stock
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Based on 1 publication(s) in Google Scholar

Azido-PEG24-acid Related Antibodies

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Description

Azido-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG24-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Azido-PEG24-acid Related Antibodies
Molecular Weight

1172.35

Formula

C51H101N3O26
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (85.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8530 mL 4.2649 mL 8.5299 mL
5 mM 0.1706 mL 0.8530 mL 1.7060 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8530 mL 4.2649 mL 8.5299 mL 21.3247 mL
5 mM 0.1706 mL 0.8530 mL 1.7060 mL 4.2649 mL
10 mM 0.0853 mL 0.4265 mL 0.8530 mL 2.1325 mL
15 mM 0.0569 mL 0.2843 mL 0.5687 mL 1.4216 mL
20 mM 0.0426 mL 0.2132 mL 0.4265 mL 1.0662 mL
25 mM 0.0341 mL 0.1706 mL 0.3412 mL 0.8530 mL
30 mM 0.0284 mL 0.1422 mL 0.2843 mL 0.7108 mL
40 mM 0.0213 mL 0.1066 mL 0.2132 mL 0.5331 mL
50 mM 0.0171 mL 0.0853 mL 0.1706 mL 0.4265 mL
60 mM 0.0142 mL 0.0711 mL 0.1422 mL 0.3554 mL
80 mM 0.0107 mL 0.0533 mL 0.1066 mL 0.2666 mL
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Azido-PEG24-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azido-PEG24-acid2195075-62-6PROTAC LinkersInhibitorinhibitorinhibit

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