2. PROTAC
  3. PROTAC Linkers
  4. Amino-PEG11-amine

Amino-PEG11-amine 

Cat. No.: HY-130411 Purity: ≥95.0%
COA Handling Instructions

Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer.

For research use only. We do not sell to patients.

Amino-PEG11-amine Chemical Structure

Amino-PEG11-amine Chemical Structure

CAS No. : 479200-82-3

Size Price Stock Quantity
5 mg USD 45 In-stock
10 mg USD 68 In-stock
50 mg USD 170 In-stock
100 mg USD 260 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Amino-PEG11-amine Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

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PEGs Alkyl-Chain Alkyl/ether

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Amino-PEG11-amine, a PEG-based (12 units) PROTAC linker used to combine two mono diethylstilbestrol (DES)-based ligands, provides an alternative strategy for preparing more selective and active ER antagonists for endocrine therapy of breast cancer[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Amino-PEG11-amine Related Antibodies
Molecular Weight

544.68

Appearance

Oil

Formula

C24H52N2O11
CAS No.
SMILES

NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (183.59 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8359 mL 9.1797 mL 18.3594 mL
5 mM 0.3672 mL 1.8359 mL 3.6719 mL
10 mM 0.1836 mL 0.9180 mL 1.8359 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.59 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.59 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.59 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Amino-PEG11-amine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Amino-PEG11-amine479200-82-3PROTAC LinkersInhibitorinhibitorinhibit

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