Diketone-PEG4-Biotin
Based on 1 Customer Validation
Diketone-PEG4-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 2353409-85-3
- Formula: C33H50N4O9S
- Molecular Weight:678.84
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2353409-85-3
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Appearance Oil
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Molecular Weight 678.84
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Formula C33H50N4O9S
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Color Colorless to light yellow
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SMILES
O=C(NCCOCCOCCOCCOCCC(NC1=CC=C(CCC(CC(C)=O)=O)C=C1)=O)CCCC[C@H]2[C@](NC3=O)([H])[C@](N3)([H])CS2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 125 mg/mL (184.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (266 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4731 mL | 7.3655 mL | 14.7310 mL | 36.8275 mL |
| 5 mM | 0.2946 mL | 1.4731 mL | 2.9462 mL | 7.3655 mL | |
| 10 mM | 0.1473 mL | 0.7366 mL | 1.4731 mL | 3.6828 mL | |
| 15 mM | 0.0982 mL | 0.4910 mL | 0.9821 mL | 2.4552 mL | |
| 20 mM | 0.0737 mL | 0.3683 mL | 0.7366 mL | 1.8414 mL | |
| 25 mM | 0.0589 mL | 0.2946 mL | 0.5892 mL | 1.4731 mL | |
| 30 mM | 0.0491 mL | 0.2455 mL | 0.4910 mL | 1.2276 mL | |
| 40 mM | 0.0368 mL | 0.1841 mL | 0.3683 mL | 0.9207 mL | |
| 50 mM | 0.0295 mL | 0.1473 mL | 0.2946 mL | 0.7366 mL | |
| 60 mM | 0.0246 mL | 0.1228 mL | 0.2455 mL | 0.6138 mL | |
| 80 mM | 0.0184 mL | 0.0921 mL | 0.1841 mL | 0.4603 mL | |
| 100 mM | 0.0147 mL | 0.0737 mL | 0.1473 mL | 0.3683 mL |
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