2. PROTAC
  3. PROTAC Linkers
  4. Diketone-PEG4-Biotin

Diketone-PEG4-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Diketone-PEG4-Biotin Chemical Structure

Diketone-PEG4-Biotin Chemical Structure

CAS No. : 2353409-85-3

Size Price Stock Quantity
5 mg USD 270 In-stock
10 mg USD 430 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Diketone-PEG4-Biotin Related Antibodies

Top Publications Citing Use of Products

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

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Description

Diketone-PEG4-Biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diketone-PEG4-Biotin Related Antibodies
Molecular Weight

678.84

Formula

C33H50N4O9S
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(NCCOCCOCCOCCOCCC(NC1=CC=C(CCC(CC(C)=O)=O)C=C1)=O)CCCC[C@H]2[C@](NC3=O)([H])[C@](N3)([H])CS2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (184.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4731 mL 7.3655 mL 14.7310 mL
5 mM 0.2946 mL 1.4731 mL 2.9462 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4731 mL 7.3655 mL 14.7310 mL 36.8275 mL
5 mM 0.2946 mL 1.4731 mL 2.9462 mL 7.3655 mL
10 mM 0.1473 mL 0.7366 mL 1.4731 mL 3.6828 mL
15 mM 0.0982 mL 0.4910 mL 0.9821 mL 2.4552 mL
20 mM 0.0737 mL 0.3683 mL 0.7366 mL 1.8414 mL
25 mM 0.0589 mL 0.2946 mL 0.5892 mL 1.4731 mL
30 mM 0.0491 mL 0.2455 mL 0.4910 mL 1.2276 mL
40 mM 0.0368 mL 0.1841 mL 0.3683 mL 0.9207 mL
50 mM 0.0295 mL 0.1473 mL 0.2946 mL 0.7366 mL
60 mM 0.0246 mL 0.1228 mL 0.2455 mL 0.6138 mL
80 mM 0.0184 mL 0.0921 mL 0.1841 mL 0.4603 mL
100 mM 0.0147 mL 0.0737 mL 0.1473 mL 0.3683 mL
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Diketone-PEG4-Biotin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diketone-PEG4-Biotin2353409-85-3PROTAC LinkersInhibitorinhibitorinhibit

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