Fmoc-aminooxy-PFP ester

Name: Fmoc-aminooxy-PFP ester
Brand: MedChemExpress
SKU: HY-133404
Rating: 4.5 (0 reviews)

Cat. No.: HY-133404: Data Sheet
COA

SDS
Handling Instructions
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Fmoc-aminooxy-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Fmoc-aminooxy-PFP ester Chemical Structure

CAS No. : 2752177-95-8

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

Fmoc-aminooxy-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

Alkyl/ether

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

479.35

Formula

C₂₃H₁₄F₅NO₅

CAS No.

2752177-95-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NOCC(OC4=C(F)C(F)=C(F)C(F)=C4F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (208.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0862 mL	10.4308 mL	20.8616 mL
5 mM	0.4172 mL	2.0862 mL	4.1723 mL
10 mM	0.2086 mL	1.0431 mL	2.0862 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 95.0%

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Data Sheet (271 KB) SDS (393 KB)

COA (248 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0862 mL	10.4308 mL	20.8616 mL	52.1540 mL
	5 mM	0.4172 mL	2.0862 mL	4.1723 mL	10.4308 mL
	10 mM	0.2086 mL	1.0431 mL	2.0862 mL	5.2154 mL
	15 mM	0.1391 mL	0.6954 mL	1.3908 mL	3.4769 mL
	20 mM	0.1043 mL	0.5215 mL	1.0431 mL	2.6077 mL
	25 mM	0.0834 mL	0.4172 mL	0.8345 mL	2.0862 mL
	30 mM	0.0695 mL	0.3477 mL	0.6954 mL	1.7385 mL
	40 mM	0.0522 mL	0.2608 mL	0.5215 mL	1.3038 mL
	50 mM	0.0417 mL	0.2086 mL	0.4172 mL	1.0431 mL
	60 mM	0.0348 mL	0.1738 mL	0.3477 mL	0.8692 mL
	80 mM	0.0261 mL	0.1304 mL	0.2608 mL	0.6519 mL
	100 mM	0.0209 mL	0.1043 mL	0.2086 mL	0.5215 mL