Prostaglandin Receptor Antagonist

Prostaglandin Receptor Antagonists (172):

Cat. No.	Product Name	Effect	Purity

HY-118388

AS604872	Antagonist
AS604872 is an orally active, potent and selective prostaglandin F2α receptor (FP) antagonist with a K_i of 35 nM in humans, 158 nM in rats and 323 nM in mice. AS604872 inhibits contractions and delays labour.

HY-101430

PGD2-IN-1	Antagonist	98.03%
PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d); has an IC₅₀ of 0.3 nM.

HY-14467

GSK-269984A	Antagonist	99.58%
GSK-269984A is a Prostaglandin E2 Receptor 1 (EP1) antagonist with a pIC₅₀ of 7.9.

HY-105218

Ifetroban	Antagonist	99.65%
Ifetroban (BMS-180291) is an orally active antagonist of thromboxane A2 (TXA2) or prostaglandin H2 (PGH2) receptor. Ifetroban shows antiplatelet activity, and inhibits tumor cell migration without affecting cell proliferation. Ifetroban can be used for myocardial ischemia, hypertension, stroke, thrombosis, cardiomyopathy research.

HY-109186

Pexopiprant	Antagonist	99.40%
Pexopiprant is an oral antagonist of the prostaglandin D2 receptor 2 (DP2),K_i ＜ 100nM. Pexopiprant can be used in studies of asthma.

HY-13213

AM211	Antagonist	98.79%
AM211 is a potent, selective and orally bioavailable prostaglandin D2 (PGD2) receptor type 2 (DP2) antagonist, with IC₅₀s of 4.9 nM, 7.8 nM, 4.9 nM, 10.4 nM for human, mouse, guinea pig, and rat DP2, respectively.

HY-101695

EP1-antagonist-1	Antagonist	98.60%
EP1-antagonist-1 (Compound 27) is an EP1 antagonist with a pK_i (FLIPR) of 9.31 and a pIC₅₀ (binding) of 9.88. EP1-antagonist-1 can be used for the study of PGE2-mediated pain.

HY-U00253

KP496	Antagonist	99.79%
KP496 is a selective, dual antagonist for Leukotriene D4 receptor and Thromboxane A2 receptor.

HY-19849

BGC-20-1531 free base	Antagonist
BGC-20-1531 (PGN 1531) free base is a potent and selective prostanoid EP₄ receptor antagonist, with a pK_B of 7.6. BGC-20-1531 free base has the potential for the research of migraine headache.

HY-149290

AMX12006	Antagonist	99.9%
AMX12006 is a potent, selective and orally active EP4 antagonist with an IC₅₀ value of 4.3 nM. AMX12006 shows cytotoxic and antitumor activity.

HY-10414

MK-2894 sodium salt	Antagonist	98.94%
MK-2894 sodium salt is a potent, selective, orally active and high affinity (K_i=0.56 nM) full antagonist against E prostanoid receptor 4 (EP4 receptor) (IC₅₀=2.5 nM). MK-2894 sodium salt possesses potent anti-inflammatory activity in animal models of pain/inflammation and can be used for the research of arthritis.

HY-19499

AMG-009	Antagonist	98.08%
AMG-009 is a potent antagonist of prostaglandin D2, with IC₅₀ of 3 nM and 12 nM for CRTH2 and DP receptors, respectively.

HY-176990

TP receptor antagonist-3	Antagonist	99.88%
TP receptor antagonist-3 (compound 51280) is a potent thromboxane A2 prostanoid (TP) receptor with an IC₅₀ of 15.7 nM against Human TP. TP receptor antagonist-3 can be used for alzheimer's disease, cardiovascular and respiratory diseases, and cancer research.

HY-108563

SC 51089	Antagonist
SC 51089 is a selective antagonist of prostaglandin E₂ EP1 receptor, with K_is of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, EP3, and FP receptors, respectively. SC 51089 exhibits neuroprotective activity.

HY-12182

ONO-8711	Antagonist
ONO-8711 is a potent and selective competitive antagonist of EP1 receptor (K_i = 0.6 and 1.7 nM for human and mouse EP1 respectively). ONO-8711 effectively reduces tumor incidence and multiplicity in mouse models of colon, breast, and oral cancer.

HY-108912R

RO1138452 (Standard)	Antagonist
RO1138452 (Standard) is the analytical standard of RO1138452. This product is intended for research and analytical applications. RO1138452 is a potent and selective IP (prostacyclin) receptor antagonist. RO1138452 displays high affinity for IP receptors. In human platelets, pKi is 9.3±0.1; in a recombinant IP receptor system, pKi is 8.7±0.06.

HY-B0774R

Seratrodast (Standard)	Antagonist
Seratrodast (Standard) is the analytical standard of Seratrodast. This product is intended for research and analytical applications. Seratrodast (AA 2414), an orally active antiasthmatic agent, is a thromboxane A2 receptor (TP) antagonist and ferroptosis inhibitor. Seratrodast reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression. Seratrodast exhibits anti-asthmatic and anti-epileptic activity.

HY-158332

Sulotroban	Antagonist	99.29%
Sulotroban (SKF-95587; BM-13177) is a selective antagonist for thromboxane A2 receptor (TXA2 Receptor). Sulotroban exhibits inhibitory activity against carbocyclic thromboxane A2- and endoperoxide-induced vasoconstrictor. Sulotroban inhibits platelets aggregation.

HY-142658

BAY-6672	Antagonist
BAY-6672, a chemical probe, is a potent and selective human Prostaglandin F (FP) receptor antagonist with an IC₅₀ value of 11 nM.

HY-50175A

Laropiprant sodium	Antagonist
Laropiprant sodium is a potent and selective DP receptor antagonist with K_i values of 0.57 nM and 2.95 nM for DP receptor and TP Receptor, respectively.

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