2. GPCR/G Protein
  3. Prostaglandin Receptor
  4. Pexopiprant

Pexopiprant is an oral antagonist of the prostaglandin D2 receptor 2 (DP2),Ki ＜ 100nM. Pexopiprant can be used in studies of asthma.

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Pexopiprant Chemical Structure

Pexopiprant Chemical Structure

CAS No. : 932708-14-0

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Based on 1 publication(s) in Google Scholar

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Description

Pexopiprant is an oral antagonist of the prostaglandin D2 receptor 2 (DP2),Ki ＜ 100nM. Pexopiprant can be used in studies of asthma[1].

IC50 & Target[1]

DP2

<100 nM (Ki)

Molecular Weight

456.27

Formula

C21H17Cl2F2NO4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)COC1=C2C(OC(F)F)=C(CC3=CC=C(Cl)C=C3)C(CC)=NC2=C(Cl)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (219.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1917 mL 10.9584 mL 21.9168 mL
5 mM 0.4383 mL 2.1917 mL 4.3834 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1917 mL 10.9584 mL 21.9168 mL 54.7921 mL
5 mM 0.4383 mL 2.1917 mL 4.3834 mL 10.9584 mL
10 mM 0.2192 mL 1.0958 mL 2.1917 mL 5.4792 mL
15 mM 0.1461 mL 0.7306 mL 1.4611 mL 3.6528 mL
20 mM 0.1096 mL 0.5479 mL 1.0958 mL 2.7396 mL
25 mM 0.0877 mL 0.4383 mL 0.8767 mL 2.1917 mL
30 mM 0.0731 mL 0.3653 mL 0.7306 mL 1.8264 mL
40 mM 0.0548 mL 0.2740 mL 0.5479 mL 1.3698 mL
50 mM 0.0438 mL 0.2192 mL 0.4383 mL 1.0958 mL
60 mM 0.0365 mL 0.1826 mL 0.3653 mL 0.9132 mL
80 mM 0.0274 mL 0.1370 mL 0.2740 mL 0.6849 mL
100 mM 0.0219 mL 0.1096 mL 0.2192 mL 0.5479 mL
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Pexopiprant Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pexopiprant932708-14-0Prostaglandin ReceptorInhibitorinhibitorinhibit

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