1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. AS604872

AS604872 is an orally active, potent and selective prostaglandin F2α receptor (FP) antagonist with a Ki of 35 nM in humans, 158 nM in rats and 323 nM in mice. AS604872 inhibits contractions and delays labour.

For research use only. We do not sell to patients.

AS604872 Chemical Structure

AS604872 Chemical Structure

CAS No. : 612532-48-6

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Description

AS604872 is an orally active, potent and selective prostaglandin F2α receptor (FP) antagonist with a Ki of 35 nM in humans, 158 nM in rats and 323 nM in mice. AS604872 inhibits contractions and delays labour[1].

In Vivo

AS604872 (10-100 mg/kg, p.o.) delays RU486-induced preterm labour. It also dose-dependently inhibits GD14-triggered labour, with a significant increase in mean time to delivery of 16.5 and 33.5 hours at 30 mg/kg and 100 mg/kg, respectively. However, the delayed effect on GD17-induced labour is less pronounced in mice[1].
AS604872 (3-120 mg/kg, i.v.) inhibits PGF 2α-triggered total synthesis of phosphatidylinositol in a dose-dependent manner and significantly reduces PGF 2α-induced uterine contractions in SD BR non-pregnant female rats, with a maximum effect of 27% at 60 mg/kg. It also inhibited spontaneous uterine contractions in pregnant rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

515.65

Formula

C28H25N3O3S2

CAS No.
SMILES

O=C([C@H]1N(CCS1)S(=O)(C2=CC=C(C3=CC=CC=C3)C=C2)=O)N[C@@H](C4=CC=CC=N4)C5=CC=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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AS604872 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
AS604872
Cat. No.:
HY-118388
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