1. Signaling Pathways
  2. Neuronal Signaling
  3. Sigma Receptor
  4. Sigma 1 Receptor Isoform
  5. Sigma 1 Receptor Modulator

Sigma 1 Receptor Modulator

Sigma 1 Receptor Modulators (2):

Cat. No. Product Name Effect Purity
  • HY-130344
    SKF 83959
    Modulator 98.93%
    SKF83959 is a potent and selective dopamine D1-like receptor partial agonist. SKF83959 Ki values for rat D1, D5, D2 and D3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 can be used for the research of Alzheimer's disease and depression.
  • HY-B1733
    Phenyltoloxamine (Bistrimin) is an antihistamine agent with sedative and analgesic effects. Phenyltoloxamine also has potent Sigma-1 receptor binding affinity (Ki: 160 nM).